Linked Life Data

11354778

Source:http://linkedlifedata.com/resource/pubmed/id/11354778

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2001-5-16
pubmed:abstractText
It has been proposed that low birth weight (LBW) results in a reduction in glomerular number that may, in turn, predispose an individual to develop hypertension in adulthood. Glomerular number is reduced in animal models of intra-uterine malnutrition using a variety of techniques. However, the relevance of such extreme models to man is uncertain. The purpose of this study was to evaluate whether animals with naturally occurring LBW, which have not received any manipulation in utero, have a reduction in glomerular number, altered glomerular volume and abnormal urine albumin excretion. Litters from female rats delivering at term on the same day were weighed and sexed at birth. From each litter 2 males with the lowest birth weight (LBW n = 18) and 2 males with a birth weight closest to the litter mean [normal birth weight (NBW) n = 18] were selected and cross-fostered onto periparturient lactating dams. LBW rats weighted 6.7 +/- 0.6 g compared with 7.2 +/- 0.6 g for NBW rats (P = 0.03). After weaning all rats were weighed weekly and underwent metabolic studies at 4, 8, 12 and 16 weeks. Following perfusion fixation, glomerular number and mean glomerular volume were estimated using standard stereological techniques. There was no significant difference between LBW and NBW rats with respect to glomerular number (24,499 +/- 2,078 vs. 24,825 +/- 1,818), mean glomerular volume and urine albumin excretion, and no rats had a glomerular number outside the normal range. This study suggests that naturally occurring LBW has little influence on renal development, glomerular number and volume.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0931-041X
pubmed:author
pubmed:issnType
Print
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
340-5
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2001
pubmed:articleTitle
Birth weight has no influence on glomerular number and volume.
pubmed:affiliation
School of Clinical Medical Sciences, Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, UK. sue@jones1385.fsnet.co.uk
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't