|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
9
|
|
pubmed:dateCreated |
2001-5-16
|
|
pubmed:abstractText |
Quinazolines have been identified as inhibitors of CDK4/D1 and CDK2/E. Aspects of the SAR were investigated using solution-phase, parallel synthesis. An X-ray crystal structure was obtained of quinazoline 51 bound in CDK2 and key interactions within the ATP binding pocket are defined.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
May
|
|
pubmed:issn |
0960-894X
|
|
pubmed:author |
pubmed-author:BenfieldP APA,
pubmed-author:BoisclairMM,
pubmed-author:BoylanJJ,
pubmed-author:BurtonC RCR,
pubmed-author:ChangC HCH,
pubmed-author:ChenHH,
pubmed-author:CoxSS,
pubmed-author:GrafstromR HRH,
pubmed-author:JohnsonT LTL,
pubmed-author:LiuJJ,
pubmed-author:MuckelbauerJ KJK,
pubmed-author:SeitzS PSP,
pubmed-author:SieleckiT MTM,
pubmed-author:SmallwoodAA,
pubmed-author:TrainorG LGL
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
7
|
|
pubmed:volume |
11
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1157-60
|
|
pubmed:dateRevised |
2009-11-19
|
|
pubmed:meshHeading |
pubmed-meshheading:11354366-Binding, Competitive,
pubmed-meshheading:11354366-Cell Line,
pubmed-meshheading:11354366-Crystallography, X-Ray,
pubmed-meshheading:11354366-Cyclin-Dependent Kinases,
pubmed-meshheading:11354366-Enzyme Inhibitors,
pubmed-meshheading:11354366-Models, Molecular,
pubmed-meshheading:11354366-Quinazolines,
pubmed-meshheading:11354366-Structure-Activity Relationship
|
|
pubmed:year |
2001
|
|
pubmed:articleTitle |
Quinazolines as cyclin dependent kinase inhibitors.
|
|
pubmed:affiliation |
The DuPont Pharmaceuticals Company, Wilmington, DE 19880-0500, USA. thais.m.sielecki@dupontpharma.com
|
|
pubmed:publicationType |
Journal Article
|
