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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2001-5-16
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pubmed:abstractText |
An effort to identify novel inhibitors of peptidoglycan synthesis with antibacterial activity resulted in the discovery of a series of biaryl urea-based antibacterial agents through isolation of a by-product from a mixture-based combinatorial library of semi-carbazones and subsequent parallel synthesis efforts. The compounds were shown to possess broad spectrum antibacterial activity against gram-positive drug resistant pathogens, and showed apparent specificity for disruption of the bacterial cell wall biosynthesis pathway.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0960-894X
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pubmed:author |
pubmed-author:BurnNN,
pubmed-author:DavisM CMC,
pubmed-author:DobsonR LRL,
pubmed-author:FOXJ VJV,
pubmed-author:HershbergerP MPM,
pubmed-author:JonesD RDR,
pubmed-author:McKeeverH DHD,
pubmed-author:MorandK LKL,
pubmed-author:MorrisT WTW,
pubmed-author:ParkerC NCN,
pubmed-author:RenickP JPJ,
pubmed-author:ShrumGG,
pubmed-author:SoperS SSS,
pubmed-author:StellaMM,
pubmed-author:SunderSS,
pubmed-author:SwitzerA GAG,
pubmed-author:WilsonL JLJ
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pubmed:issnType |
Print
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pubmed:day |
7
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1149-52
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:11354364-Anti-Bacterial Agents,
pubmed-meshheading:11354364-Bacteria,
pubmed-meshheading:11354364-Cell Wall,
pubmed-meshheading:11354364-Chemistry, Physical,
pubmed-meshheading:11354364-Chromatography, High Pressure Liquid,
pubmed-meshheading:11354364-Combinatorial Chemistry Techniques,
pubmed-meshheading:11354364-Hydrazines,
pubmed-meshheading:11354364-Mass Spectrometry,
pubmed-meshheading:11354364-Microbial Sensitivity Tests,
pubmed-meshheading:11354364-Physicochemical Phenomena,
pubmed-meshheading:11354364-Urea
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pubmed:year |
2001
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pubmed:articleTitle |
The identification and characterization of hydrazinyl urea-based antibacterial agents through combinatorial chemistry.
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pubmed:affiliation |
Procter & Gamble Pharmaceuticals, Healthcare Research Center, Mason, OH 45040, USA. lwilson3@prius.jnj.com
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pubmed:publicationType |
Journal Article
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