11339845

Source:http://linkedlifedata.com/resource/pubmed/id/11339845

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0035820, umls-concept:C0036588, umls-concept:C0231202, umls-concept:C0542329, umls-concept:C1504389, umls-concept:C1515895, umls-concept:C1527148, umls-concept:C1881865
pubmed:issue	4
pubmed:dateCreated	2001-5-7
pubmed:abstractText	The discovery of human leukocyte antigen (HLA) molecules and their role in allorecognition has facilitated the initiation of allogeneic stem cell transplantation in human beings. HLA mismatch to a large extent explains the phenomenon of graft rejection and graft versus host disease (GvHD). Incidence of GvHD even in syngeneic transplants suggests a role for extra genetic factors in the causation of GvHD. We hereby propose a hypothesis that the definition of 'self' (in the immunological sense) should be broadened to include both genetically determined molecules (e.g. HLA) and the microbial flora that colonize an individual. This hypothesis explains several observations about GvHD which can not fully be accounted for by the HLA mismatch theory and gives some clues towards circumventing GvHD.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/7505668
pubmed:citationSubset	IM
pubmed:status	MEDLINE
pubmed:month	Apr
pubmed:issn	0306-9877
pubmed:author	pubmed-author:GuptaSS, pubmed-author:KochupillaiVV, pubmed-author:RajuG MGM, pubmed-author:SinghH PHP
pubmed:copyrightInfo	Copyright 2001 Harcourt Publishers Ltd.
pubmed:issnType	Print
pubmed:volume	56
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	448-50
pubmed:dateRevised	2004-11-17
pubmed:meshHeading	pubmed-meshheading:11339845-Age Factors, pubmed-meshheading:11339845-Graft vs Host Disease, pubmed-meshheading:11339845-Hematopoietic Stem Cell Transplantation, pubmed-meshheading:11339845-Humans, pubmed-meshheading:11339845-Transplantation, Homologous
pubmed:year	2001
pubmed:articleTitle	Redefining 'self': the role of microflora (commensals) mismatch in the development of GvHD after allogeneic stem cell transplantation and some possible remedies.
pubmed:affiliation	Department of Medical Oncology, Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India.
pubmed:publicationType	Journal Article