|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
10
|
|
pubmed:dateCreated |
2001-5-3
|
|
pubmed:abstractText |
A series of 3beta-naphthyltropane derivatives were synthesized and found to show high affinity at both the dopamine and serotonin transporter sites, leading to some of the most potent inhibitors known based on the tropane structure. Comparative molecular field analysis (CoMFA) models were developed for both dopamine and serotonin transporter binding data. These models provide insights into those factors that influence binding at the two transporters.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Dopamine Plasma Membrane Transport...,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Transport Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Norepinephrine,
http://linkedlifedata.com/resource/pubmed/chemical/Norepinephrine Plasma Membrane...,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin Plasma Membrane...,
http://linkedlifedata.com/resource/pubmed/chemical/Slc6a2 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Slc6a4 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Symporters,
http://linkedlifedata.com/resource/pubmed/chemical/Tropanes
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
May
|
|
pubmed:issn |
0022-2623
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
10
|
|
pubmed:volume |
44
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1509-15
|
|
pubmed:dateRevised |
2007-11-14
|
|
pubmed:meshHeading |
pubmed-meshheading:11334561-Animals,
pubmed-meshheading:11334561-Binding, Competitive,
pubmed-meshheading:11334561-Carrier Proteins,
pubmed-meshheading:11334561-Corpus Striatum,
pubmed-meshheading:11334561-Dopamine,
pubmed-meshheading:11334561-Dopamine Plasma Membrane Transport Proteins,
pubmed-meshheading:11334561-Frontal Lobe,
pubmed-meshheading:11334561-Membrane Glycoproteins,
pubmed-meshheading:11334561-Membrane Transport Proteins,
pubmed-meshheading:11334561-Models, Molecular,
pubmed-meshheading:11334561-Nerve Tissue Proteins,
pubmed-meshheading:11334561-Norepinephrine,
pubmed-meshheading:11334561-Norepinephrine Plasma Membrane Transport Proteins,
pubmed-meshheading:11334561-Radioligand Assay,
pubmed-meshheading:11334561-Rats,
pubmed-meshheading:11334561-Rats, Sprague-Dawley,
pubmed-meshheading:11334561-Serotonin,
pubmed-meshheading:11334561-Serotonin Plasma Membrane Transport Proteins,
pubmed-meshheading:11334561-Structure-Activity Relationship,
pubmed-meshheading:11334561-Symporters,
pubmed-meshheading:11334561-Tropanes
|
|
pubmed:year |
2001
|
|
pubmed:articleTitle |
Synthesis of 2beta-acyl-3beta-(substituted naphthyl)-8-azabicyclo[3.2.1]octanes and their binding affinities at dopamine and serotonin transport sites.
|
|
pubmed:affiliation |
Department of Chemistry, State University of New York at Buffalo, Buffalo, New York 14260-3000, USA. hdavies@acsu.buffalo.edu
|
|
pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.
|
