Source:http://linkedlifedata.com/resource/pubmed/id/11331396
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
10
|
| pubmed:dateCreated |
2001-5-24
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| pubmed:abstractText |
The limited plastic and regenerative capabilities of axons in the adult mammalian CNS can be enhanced by the application of a monoclonal antibody (mAb), IN-1, raised against the myelin-associated neurite growth inhibitor Nogo-A. The aim of the present study was to investigate the effects of this treatment on the functional recovery of adult rats with a dorsal over-hemisection of the spinal cord. Directly after injury, half of the animals were implanted with mAb IN-1-secreting hybridoma cells, whereas the others received cells secreting a control antibody (anti-HRP). A broad spectrum of locomotor tests (open field locomotor) score, grid walk, misstep withdrawal response, narrow-beam crossing) was used to characterize locomotor recovery during the 5 weeks after the injury. In all behavioral tests, the recovery in the mAb IN-1-treated group was significantly augmented compared with the control antibody-treated rats. EMG recordings of flexor and extensor muscles during treadmill walking confirmed the improvement of the locomotor pattern in the mAb IN-1-treated rats; step-cycle duration, rhythmicity, and coupling of the hindlimbs were significantly improved. No differences between the two groups with regard to nociception were observed in the tail flick test 5 weeks after the operation. These results indicating improved functional recovery suggest that the increased plastic and regenerative capabilities of the CNS after Nogo-A neutralization result in a functionally meaningful rewiring of the motor systems.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
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| pubmed:issn |
1529-2401
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:day |
15
|
| pubmed:volume |
21
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
3665-73
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:11331396-Animals,
pubmed-meshheading:11331396-Antibodies, Monoclonal,
pubmed-meshheading:11331396-Axotomy,
pubmed-meshheading:11331396-Behavior, Animal,
pubmed-meshheading:11331396-Disease Models, Animal,
pubmed-meshheading:11331396-Electromyography,
pubmed-meshheading:11331396-Female,
pubmed-meshheading:11331396-Growth Inhibitors,
pubmed-meshheading:11331396-Hindlimb,
pubmed-meshheading:11331396-Locomotion,
pubmed-meshheading:11331396-Male,
pubmed-meshheading:11331396-Motor Activity,
pubmed-meshheading:11331396-Myelin Proteins,
pubmed-meshheading:11331396-Neurites,
pubmed-meshheading:11331396-Pain Measurement,
pubmed-meshheading:11331396-Rats,
pubmed-meshheading:11331396-Rats, Inbred Lew,
pubmed-meshheading:11331396-Recovery of Function,
pubmed-meshheading:11331396-Spinal Cord Injuries
|
| pubmed:year |
2001
|
| pubmed:articleTitle |
Locomotor recovery in spinal cord-injured rats treated with an antibody neutralizing the myelin-associated neurite growth inhibitor Nogo-A.
|
| pubmed:affiliation |
Department of Neuromorphology, Brain Research Institute, University and Swiss Federal Institute of Technology Zürich, 8057 Zürich, Switzerland.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|