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rdf:type |
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lifeskim:mentions |
umls-concept:C0003316,
umls-concept:C0005516,
umls-concept:C0017262,
umls-concept:C0019721,
umls-concept:C0021745,
umls-concept:C0031689,
umls-concept:C0039194,
umls-concept:C0039195,
umls-concept:C0085358,
umls-concept:C0175630,
umls-concept:C0185117,
umls-concept:C0205725,
umls-concept:C1332717,
umls-concept:C1413244,
umls-concept:C1706438,
umls-concept:C2698600,
umls-concept:C2911684
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pubmed:issue |
3
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pubmed:dateCreated |
2001-5-1
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pubmed:abstractText |
Antigen-specific CD8(+) T cells with cytotoxic activity are often critical in immune responses to infectious pathogens. To determine whether gamma interferon (IFN-gamma) expression is a surrogate marker for cytotoxic T lymphocytes (CTL), human cytomegalovirus-specific CTL responses were correlated with CD8(+) T-cell IFN-gamma expression determined by cytokine flow cytometry. A strong positive correlation was observed between specific lysis of peptide-pulsed targets in a (51)Cr release assay and frequencies of peptide-activated CD8(+) T cells expressing IFN-gamma at 6 h (r(2) = 0.72) or 7 days (r(2) = 0.91). Enumeration of responding cells expressing perforin, another marker associated with CTL, did not improve this correlation. These results demonstrate that IFN-gamma expression can be a functional surrogate for identification of CTL precursor cells.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/11329470-10330434,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11329470-10371507,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11329470-10485708,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11329470-10556194,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11329470-10754518,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11329470-10843378,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11329470-10898504,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11329470-10946264,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11329470-11049989,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11329470-1356428,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11329470-1731326,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11329470-7734048,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11329470-7734049,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11329470-7759869,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11329470-8164737,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11329470-8499074,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11329470-8574849,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11329470-8600537,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11329470-8794011,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11329470-8810254,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11329470-9120019,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11329470-9491999,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11329470-9548456,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11329470-9558065,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11329470-9701254,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11329470-9822306
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1071-412X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
628-31
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:11329470-Antigen Presentation,
pubmed-meshheading:11329470-Antigens, Viral,
pubmed-meshheading:11329470-Biological Markers,
pubmed-meshheading:11329470-CD8-Positive T-Lymphocytes,
pubmed-meshheading:11329470-Cytomegalovirus,
pubmed-meshheading:11329470-Cytotoxicity, Immunologic,
pubmed-meshheading:11329470-HLA-A2 Antigen,
pubmed-meshheading:11329470-Humans,
pubmed-meshheading:11329470-Interferon-gamma,
pubmed-meshheading:11329470-Phosphoproteins
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pubmed:year |
2001
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pubmed:articleTitle |
Gamma interferon expression in CD8(+) T cells is a marker for circulating cytotoxic T lymphocytes that recognize an HLA A2-restricted epitope of human cytomegalovirus phosphoprotein pp65.
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pubmed:affiliation |
BD Biosciences, Immunocytometry Systems, San Jose, California 95131, USA. smita_ghanekar@bdis.com
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pubmed:publicationType |
Journal Article
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