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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2001-4-30
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pubmed:abstractText |
The genome is constantly assaulted by oxidation reactions which are likely to be associated with oxygen metabolism, and oxidative lesions are generated by many types of oxidants. Such genotoxin-induced alterations in the genomic message have been implicated in aging and in several pathophysiological processes, particularly those associated with cancer. The guanine base (G) in genomic DNA is highly susceptible to oxidative stress due to having the lowest oxidation potential. Therefore, G-C-->T-A and G-C-->C-G transversion mutations frequently occur under oxidative conditions. One typical lesion of G is 8-oxo-7,8-dihydro-guanine (8-oxoG), which can pair with A. This pairing may cause G-C-->T-A transversion mutations. Although the number of G-C-->C-G transversions is rather high under specific oxidation conditions such as riboflavin photosensitization, the molecular basis of G-C-->C-G transversions is not known.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/8-hydroxyguanine,
http://linkedlifedata.com/resource/pubmed/chemical/9,10-anthraquinone 2-carboxylic acid,
http://linkedlifedata.com/resource/pubmed/chemical/Anthraquinones,
http://linkedlifedata.com/resource/pubmed/chemical/Carboxylic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Cytosine,
http://linkedlifedata.com/resource/pubmed/chemical/DNA,
http://linkedlifedata.com/resource/pubmed/chemical/Guanine,
http://linkedlifedata.com/resource/pubmed/chemical/Imidazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Oligodeoxyribonucleotides,
http://linkedlifedata.com/resource/pubmed/chemical/Oxidants,
http://linkedlifedata.com/resource/pubmed/chemical/Riboflavin,
http://linkedlifedata.com/resource/pubmed/chemical/imidazolone
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1074-5521
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
369-78
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:11325592-Anthraquinones,
pubmed-meshheading:11325592-Base Pairing,
pubmed-meshheading:11325592-Base Sequence,
pubmed-meshheading:11325592-Carboxylic Acids,
pubmed-meshheading:11325592-Chromatography, High Pressure Liquid,
pubmed-meshheading:11325592-Cytosine,
pubmed-meshheading:11325592-DNA,
pubmed-meshheading:11325592-DNA Damage,
pubmed-meshheading:11325592-Guanine,
pubmed-meshheading:11325592-Imidazoles,
pubmed-meshheading:11325592-Kinetics,
pubmed-meshheading:11325592-Mutagenesis,
pubmed-meshheading:11325592-Oligodeoxyribonucleotides,
pubmed-meshheading:11325592-Oxidants,
pubmed-meshheading:11325592-Oxidative Stress,
pubmed-meshheading:11325592-Photochemistry,
pubmed-meshheading:11325592-Point Mutation,
pubmed-meshheading:11325592-Riboflavin,
pubmed-meshheading:11325592-Static Electricity,
pubmed-meshheading:11325592-Temperature,
pubmed-meshheading:11325592-Ultraviolet Rays
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pubmed:year |
2001
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pubmed:articleTitle |
Possible cause of G-C-->C-G transversion mutation by guanine oxidation product, imidazolone.
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pubmed:affiliation |
Division of Biofuctional Molecules, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Surugadai, Kanda, Chiyoda, 101-0062, Tokyo, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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