Source:http://linkedlifedata.com/resource/pubmed/id/11319558
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
2001-4-25
|
| pubmed:abstractText |
Homer proteins are a family of multidomain cytosolic proteins that have been postulated to serve as scaffold proteins that affect responses to extracellular signals by regulating protein-protein interactions. We tested whether Homer proteins are involved in axon pathfinding in vivo, by expressing both wild-type and mutant isoforms of Homer in Xenopus optic tectal neurons. Time-lapse imaging demonstrated that interfering with the ability of endogenous Homer to form protein-protein interactions resulted in axon pathfinding errors at stereotypical choice points. These data demonstrate a function for scaffold proteins such as Homer in axon guidance. Homer may facilitate signal transduction from cell-surface receptors to intracellular proteins that govern the establishment of axon trajectories.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
1097-6256
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
4
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
499-506
|
| pubmed:dateRevised |
2007-11-15
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| pubmed:meshHeading |
pubmed-meshheading:11319558-Animals,
pubmed-meshheading:11319558-Axons,
pubmed-meshheading:11319558-Blotting, Western,
pubmed-meshheading:11319558-Carrier Proteins,
pubmed-meshheading:11319558-Central Nervous System,
pubmed-meshheading:11319558-Electroporation,
pubmed-meshheading:11319558-Heterozygote,
pubmed-meshheading:11319558-Image Processing, Computer-Assisted,
pubmed-meshheading:11319558-Immunohistochemistry,
pubmed-meshheading:11319558-Ligands,
pubmed-meshheading:11319558-Neuropeptides,
pubmed-meshheading:11319558-Oocytes,
pubmed-meshheading:11319558-Organ Culture Techniques,
pubmed-meshheading:11319558-Rats,
pubmed-meshheading:11319558-Signal Transduction,
pubmed-meshheading:11319558-Superior Colliculi,
pubmed-meshheading:11319558-Vaccinia virus,
pubmed-meshheading:11319558-Xenopus
|
| pubmed:year |
2001
|
| pubmed:articleTitle |
The scaffold protein, Homer1b/c, regulates axon pathfinding in the central nervous system in vivo.
|
| pubmed:affiliation |
Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|