Source:http://linkedlifedata.com/resource/pubmed/id/11315487
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
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| pubmed:dateCreated |
2001-4-23
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| pubmed:abstractText |
The alkali hydroxide content in soda lime induces Compound A formation from Sevoflurane (Sevo). This study was designed to answer the question if the use of potassium hydroxide-free Soda Lime (SL) would lead to lower Compound A levels as compared to Sodasorb (SO). A total of 30 patients scheduled for elective laparoscopic cholecystectomy received Sevo anaesthesia under low-flow conditions (0.8 l/min fresh gas flow). Each absorbent was used in 15 patients, but 3 patients of the SO group were excluded due to technical problems with Compound A analysis. Hemodynamic parameters, parameters of ventilation and gas concentrations were documented. Compound A concentrations were measured by gas chromatography from gas samples before Sevo application and 20, 40, 60, 90 and 120 min after low-flow start. Mean endtidal Sevo concentrations were 1.94 +/- 0.17 (SO) and 1.97 +/- 0.15 (SL) vol %, the total anaesthetic exposition was 1.52 +/- 0.36 (SO) and 1.64 +/- 0.47 (SL) MAC-h (n.s). The maximum Compound A concentration was significantly higher in SL group (19.6 +/- 2.8 vs. 11.7 +/- 4.1 ppm, p < 0.001). Therefore, elimination of potassium hydroxide from carbon dioxide absorbents alone did not lead to a reduction of Compound A formation during low-flow anaesthesia.
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| pubmed:language |
ger
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anesthetics, Inhalation,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Carbon Dioxide,
http://linkedlifedata.com/resource/pubmed/chemical/Ethers,
http://linkedlifedata.com/resource/pubmed/chemical/Hydrocarbons, Fluorinated,
http://linkedlifedata.com/resource/pubmed/chemical/Hydroxides,
http://linkedlifedata.com/resource/pubmed/chemical/Methyl Ethers,
http://linkedlifedata.com/resource/pubmed/chemical/Oxides,
http://linkedlifedata.com/resource/pubmed/chemical/Sodium Hydroxide,
http://linkedlifedata.com/resource/pubmed/chemical/fluoromethyl...,
http://linkedlifedata.com/resource/pubmed/chemical/sevoflurane,
http://linkedlifedata.com/resource/pubmed/chemical/soda lime
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| pubmed:status |
MEDLINE
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| pubmed:month |
Mar
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| pubmed:issn |
0003-2417
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
50
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
155-61
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| pubmed:dateRevised |
2007-11-15
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| pubmed:meshHeading |
pubmed-meshheading:11315487-Anesthesia, Inhalation,
pubmed-meshheading:11315487-Anesthetics, Inhalation,
pubmed-meshheading:11315487-Calcium Compounds,
pubmed-meshheading:11315487-Carbon Dioxide,
pubmed-meshheading:11315487-Cholecystectomy, Laparoscopic,
pubmed-meshheading:11315487-Chromatography, Gas,
pubmed-meshheading:11315487-Ethers,
pubmed-meshheading:11315487-Hemodynamics,
pubmed-meshheading:11315487-Humans,
pubmed-meshheading:11315487-Hydrocarbons, Fluorinated,
pubmed-meshheading:11315487-Hydroxides,
pubmed-meshheading:11315487-Methyl Ethers,
pubmed-meshheading:11315487-Oxides,
pubmed-meshheading:11315487-Sodium Hydroxide
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| pubmed:year |
2001
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| pubmed:articleTitle |
[Low alkali-hydroxide content in soda limes does not lead to reduction of compound A formation from sevoflurane during low-flow anesthesia].
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| pubmed:affiliation |
Klinik für Anästhesiologie, Ludwig-Maximilians-Universität München, Klinikum Grosshadern, Marchioninistrasse 15, 81366 München. florian.reichle@ana.med.uni-muenchen.de
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| pubmed:publicationType |
Journal Article,
Clinical Trial,
English Abstract
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