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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2001-4-20
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pubmed:abstractText |
Kainate receptor activation depresses synaptic release of neurotransmitter at a number of synapses in the CNS. The mechanism underlying this depression is controversial, and both ionotropic and metabotropic mechanisms have been suggested. We report here that the AMPA/kainate receptor agonists domoate (DA) and kainate (KA) cause a presynaptic depression of glutamatergic transmission at CA3-->CA1 synapses in the hippocampus, which is not blocked by the AMPA receptor antagonist GYKI 53655 but is blocked by the AMPA/KA receptor antagonist CNQX. Neither a blockade of interneuronal discharge nor antagonists of several neuromodulators affect the depression, suggesting that it is not the result of indirect excitation and subsequent release of a neuromodulator. Presynaptic depolarization, achieved via increasing extracellular K(+), caused a depression of the presynaptic fiber volley and an increase in the frequency of miniature EPSCs. Neither effect was observed with DA, suggesting that DA does not depress transmission via a presynaptic depolarization. However, the effects of DA were abolished by the G-protein inhibitors N-ethylmaleimide and pertussis toxin. These results suggest that KA receptor activation depresses synaptic transmission at this synapse via a direct, presynaptic, metabotropic action.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Ethylmaleimide,
http://linkedlifedata.com/resource/pubmed/chemical/Excitatory Amino Acid Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Excitatory Amino Acid Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/GTP-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Kainic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Pertussis Toxin,
http://linkedlifedata.com/resource/pubmed/chemical/Potassium,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, AMPA,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Kainic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Virulence Factors, Bordetella,
http://linkedlifedata.com/resource/pubmed/chemical/domoic acid
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1529-2401
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
21
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2958-66
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11312279-Animals,
pubmed-meshheading:11312279-Dose-Response Relationship, Drug,
pubmed-meshheading:11312279-Enzyme Inhibitors,
pubmed-meshheading:11312279-Ethylmaleimide,
pubmed-meshheading:11312279-Excitatory Amino Acid Agonists,
pubmed-meshheading:11312279-Excitatory Amino Acid Antagonists,
pubmed-meshheading:11312279-Excitatory Postsynaptic Potentials,
pubmed-meshheading:11312279-GTP-Binding Proteins,
pubmed-meshheading:11312279-Hippocampus,
pubmed-meshheading:11312279-Kainic Acid,
pubmed-meshheading:11312279-Patch-Clamp Techniques,
pubmed-meshheading:11312279-Pertussis Toxin,
pubmed-meshheading:11312279-Potassium,
pubmed-meshheading:11312279-Rats,
pubmed-meshheading:11312279-Rats, Sprague-Dawley,
pubmed-meshheading:11312279-Receptors, AMPA,
pubmed-meshheading:11312279-Receptors, Kainic Acid,
pubmed-meshheading:11312279-Synapses,
pubmed-meshheading:11312279-Synaptic Transmission,
pubmed-meshheading:11312279-Virulence Factors, Bordetella
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pubmed:year |
2001
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pubmed:articleTitle |
Kainate receptors depress excitatory synaptic transmission at CA3-->CA1 synapses in the hippocampus via a direct presynaptic action.
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pubmed:affiliation |
Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California 94143-0450, USA.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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