Source:http://linkedlifedata.com/resource/pubmed/id/11304163
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
9
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pubmed:dateCreated |
2001-4-17
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pubmed:abstractText |
Stability constants were measured for complexes formed between a modified DTPA ligand and the metal ions Gd(III), Eu(III), Fe(III), Ca(II), Cu(II), and Zn(II) at 25 degrees C in 0.1 M NaClO4. The gadolinium complex of this ligand is MS-325, a novel blood pool contrast agent for magnetic resonance imaging currently undergoing clinical trials. Stability constants were determined by 4 different methods: direct pH titration, pH titration with competition by EDTA, competition with DTPA using an HPLC-MS detection system, and competition with Eu(III) by monitoring equilibrium by luminescence spectroscopy. The 1:1 stability constants, log beta101, are the following: Gd, 22.06 (23.2 in 0.1 M Me4NCl); Eu, 22.21; Fe, 26.66; Ca, 10.45; Cu, 21.3; Zn, 17.82. The exchange kinetics of the Gd complex, MS-325, with the radioactive tracer (152,154)Eu were studied at 25 degrees C in 0.1 M NaClO4. The exchange reaction has acid-dependent and acid-independent terms. The rate expression is given by the following: R = k(a)[GdL][H]2 + kb[GdL][Gd][H] + kc[GdL][Gd]. The rate constants were determined to be the following: k(a) = 1.84 x 10(6) M(-2) x min(-1), kb = 2.87 x 10(3) M(-2) x min(-1), kc = 3.72 x 10(-3) M(-1) x min(-1). MS-325 is 2-3 times more stable than GdDTPA at pH 7.4 and is 10-100 times more kinetically inert.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Chelating Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Contrast Media,
http://linkedlifedata.com/resource/pubmed/chemical/Copper,
http://linkedlifedata.com/resource/pubmed/chemical/Europium,
http://linkedlifedata.com/resource/pubmed/chemical/Ferric Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Gadolinium,
http://linkedlifedata.com/resource/pubmed/chemical/Organometallic Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/gadofosveset trisodium
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0020-1669
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
23
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pubmed:volume |
40
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2170-6
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pubmed:dateRevised |
2004-6-29
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pubmed:meshHeading |
pubmed-meshheading:11304163-Chelating Agents,
pubmed-meshheading:11304163-Contrast Media,
pubmed-meshheading:11304163-Copper,
pubmed-meshheading:11304163-Drug Stability,
pubmed-meshheading:11304163-Europium,
pubmed-meshheading:11304163-Ferric Compounds,
pubmed-meshheading:11304163-Gadolinium,
pubmed-meshheading:11304163-Kinetics,
pubmed-meshheading:11304163-Magnetic Resonance Imaging,
pubmed-meshheading:11304163-Organometallic Compounds,
pubmed-meshheading:11304163-Potentiometry,
pubmed-meshheading:11304163-Thermodynamics
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pubmed:year |
2001
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pubmed:articleTitle |
Thermodynamic stability and kinetic inertness of MS-325, a new blood pool agent for magnetic resonance imaging.
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pubmed:affiliation |
EPIX Medical, Inc., 71 Rogers Street, Cambridge, Massachusetts 02142-1118, USA.
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pubmed:publicationType |
Journal Article
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