11303953

Source:http://linkedlifedata.com/resource/pubmed/id/11303953

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0022702, umls-concept:C0031164, umls-concept:C0242643
pubmed:issue	12
pubmed:dateCreated	2001-4-16
pubmed:abstractText	The objectives of this work were to evaluate the importance of moderate passive permeability on apparent P-glycoprotein (P-gp) kinetics, and demonstrate that inspection of basolateral to apical and apical to basolateral (BL-AP/AP-BL) permeability ratios may result in a compound being overlooked as a P-gp substrate and inhibitor of another drug's transport via P-gp inhibition.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/8406521
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/P-Glycoproteins
pubmed:status	MEDLINE
pubmed:month	Dec
pubmed:issn	0724-8741
pubmed:author	pubmed-author:HumphreysJ EJE, pubmed-author:LeushS SSS, pubmed-author:PolliJ EJE, pubmed-author:PolliJ WJW, pubmed-author:WringS ASA
pubmed:issnType	Print
pubmed:volume	17
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	1456-60
pubmed:dateRevised	2006-11-15
pubmed:meshHeading	pubmed-meshheading:11303953-Algorithms, pubmed-meshheading:11303953-Caco-2 Cells, pubmed-meshheading:11303953-Cell Membrane Permeability, pubmed-meshheading:11303953-Drug Interactions, pubmed-meshheading:11303953-Humans, pubmed-meshheading:11303953-Models, Biological, pubmed-meshheading:11303953-P-Glycoproteins, pubmed-meshheading:11303953-Pharmacokinetics
pubmed:year	2000
pubmed:articleTitle	Influence of passive permeability on apparent P-glycoprotein kinetics.
pubmed:affiliation	School of Pharmacy, University of Maryland, Baltimore 21201, USA.
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't