Linked Life Data

11303904

Source:http://linkedlifedata.com/resource/pubmed/id/11303904

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2001-4-16
pubmed:abstractText
Frizzled 2 acts as a 7-transmembrane receptor in the Wnt-Dishevelled signal transduction cascade. Among others, this cascade has been associated with neural crest cell proliferation and early migration during development in mammals. The genes for some components of this cascade are located in chromosomal regions that are deleted in human syndromes associated with neural crest cell defects, like DiGeorge and Velo-Cardio-Facial Syndrome. These syndromes are often accompanied by abnormalities in cardiac morphology. Furthermore, we have reported in previous studies the upregulation of the tissue polarity gene frizzled 2 in myofibroblasts during their migration into the necrotic area after myocardial infarction in the adult heart. It is known that genes that are upregulated during cardiac remodeling due to pathology often play a role during development. To investigate whether frizzled 2 can be associated with the process of cardiac morphogenesis we studied its expression in the thoracic arterial system and heart of mouse embryo's of 10, 12, 14, 16 and 18 days after conception by means of in situ hybridization. At day 10 after conception signal could be found in the pharyngeal arches and arch arteries. The outflow tract, the ascending aorta and the pulmonary trunk were positive for frizzled 2 from day 12 on. This expression decreased with time and at day 18 only some signal could be detected in the aorta and pulmonary trunk. In contrast, in coronary and pulmonary arteries no expression was observed at any time point. Minor myocardial expression was observed in the ventricular septum at days 12 and 14. Atrial expression, although considerably lower than ventricular expression, could be detected somewhat later at days 14 and 16. Our results indicate that there is transient expression of frizzled 2 in areas that are invested by neural crest cells. This expression is downregulated upon neural crest cell differentiation. The frizzled 2 expression supports a role for the Wnt-frizzled pathway in neural crest-related disorders.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0340-2061
pubmed:author
pubmed:issnType
Print
pubmed:volume
203
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
185-92
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:11303904-Actins, pubmed-meshheading:11303904-Animals, pubmed-meshheading:11303904-Apoptosis, pubmed-meshheading:11303904-Cell Division, pubmed-meshheading:11303904-Cell Movement, pubmed-meshheading:11303904-Embryonic and Fetal Development, pubmed-meshheading:11303904-Fluorescent Antibody Technique, Indirect, pubmed-meshheading:11303904-Frizzled Receptors, pubmed-meshheading:11303904-Heart, pubmed-meshheading:11303904-In Situ Hybridization, pubmed-meshheading:11303904-In Situ Nick-End Labeling, pubmed-meshheading:11303904-Mice, pubmed-meshheading:11303904-Myocardium, pubmed-meshheading:11303904-Neural Crest, pubmed-meshheading:11303904-RNA, pubmed-meshheading:11303904-Receptors, G-Protein-Coupled, pubmed-meshheading:11303904-Receptors, Neurotransmitter, pubmed-meshheading:11303904-Thoracic Arteries
pubmed:year
2001
pubmed:articleTitle
Frizzled 2 is transiently expressed in neural crest-containing areas during development of the heart and great arteries in the mouse.
pubmed:affiliation
Department of Pharmacology, Universiteit Maastricht, The Netherlands.
pubmed:publicationType
Journal Article