Linked Life Data

11299275

Source:http://linkedlifedata.com/resource/pubmed/id/11299275

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2001-4-12
pubmed:abstractText
This study investigated whether adenosine mediates the decrease in plasma renin activity (PRA) during acute hypoxia. Eight chronically tracheotomized, conscious beagle dogs were kept under standardized environmental conditions and received a low-sodium diet (0.5 mmol.kg body wt(-1).day(-1)). During the experiments, the dogs were breathing spontaneously via a ventilator circuit: first hour, normoxia (21% inspiratory concentration of O(2)); second and third hours, hypoxia (10% inspiratory concentration of O(2)). Each of the eight dogs was studied twice in randomized order in control and theophylline experiments. In theophylline experiments, theophylline, an A(1)-receptor antagonist, was infused intravenously during hypoxia (loading dose: 3 mg/kg within 30 min, maintenance: 0.5 mg. kg(-1). h(-1)). In theophylline experiments, PRA (5.9 +/- 0.8 ng ANG I. ml(-1). h(-1)) and ANG II plasma concentration (15.9 +/- 2.3 pg/ml) did not decrease during hypoxia, whereas plasma aldosterone concentration decreased from 277 +/- 63 to 132 +/- 23 pg/ml (P < 0.05). In control experiments, PRA decreased from 6.8 +/- 0.8 during normoxia to 3.0 +/- 0.5 ng ANG I. ml(-1). h(-1) during hypoxia, ANG II decreased from 13.3 +/- 1.9 to 7.3 +/- 1.9 pg/ml, and plasma aldosterone concentration decreased from 316 +/- 50 to 70 +/- 13 pg/ml (P < 0.05). Thus infusion of the adenosine receptor antagonist theophylline inhibited the suppression of the renin-angiotensin system during acute hypoxia. The decrease in aldosterone occurred independently and is apparently directly related to hypoxia. In conclusion, it is likely that adenosine mediates the decrease in PRA during acute hypoxia in conscious dogs.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
8750-7587
pubmed:author
pubmed:issnType
Print
pubmed:volume
90
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1842-8
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed-meshheading:11299275-Acute Disease, pubmed-meshheading:11299275-Adenosine, pubmed-meshheading:11299275-Aldosterone, pubmed-meshheading:11299275-Angiotensin I, pubmed-meshheading:11299275-Angiotensin II, pubmed-meshheading:11299275-Animals, pubmed-meshheading:11299275-Anoxia, pubmed-meshheading:11299275-Blood Pressure, pubmed-meshheading:11299275-Carbon Dioxide, pubmed-meshheading:11299275-Consciousness, pubmed-meshheading:11299275-Diet, Sodium-Restricted, pubmed-meshheading:11299275-Dogs, pubmed-meshheading:11299275-Female, pubmed-meshheading:11299275-Heart Rate, pubmed-meshheading:11299275-Hemodynamics, pubmed-meshheading:11299275-Oxygen, pubmed-meshheading:11299275-Partial Pressure, pubmed-meshheading:11299275-Potassium, pubmed-meshheading:11299275-Purinergic P1 Receptor Antagonists, pubmed-meshheading:11299275-Renin, pubmed-meshheading:11299275-Renin-Angiotensin System, pubmed-meshheading:11299275-Theophylline
pubmed:year
2001
pubmed:articleTitle
Evidence that the renin decrease during hypoxia is adenosine mediated in conscious dogs.
pubmed:affiliation
Experimental Anesthesia, Clinics of Anesthesiology and Operative Intensive Care Medicine, Charité, D-13353 Berlin, Germany.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't