Linked Life Data

11284666

Source:http://linkedlifedata.com/resource/pubmed/id/11284666

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2001-4-3
pubmed:abstractText
The coronary arteries are a common site of atherosclerotic plaque formation, which has been putatively linked to hemodynamic and mass transport patterns. The purpose of this paper was to study mass transport patterns in a human right coronary artery (RCA) model, focusing on the effects of local geometric features on mass transfer from blood to artery walls. Using a previously developed characteristic/finite element scheme for solving advection-dominated transport problems, mass transfer calculations were performed in a rigid, anatomically realistic model of a human RCA. A qualitative and quantitative examination of the RCA geometry was also carried out. The concentration field within the RCA was seen to closely follow primary and secondary flow features. Local variations in mass transfer patterns due to geometric features were significant and much larger in magnitude than local variations in wall shear stress. We conclude that the complex secondary flows in a realistic arterial model can produce very substantial local variations in blood-wall mass transfer rates, and may be important in atherogenesis. Further, RCA mass transfer patterns are more sensitive to local geometric features than are wall shear stress patterns.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0090-6964
pubmed:author
pubmed:issnType
Print
pubmed:volume
29
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
121-7
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
2001
pubmed:articleTitle
Mass transport in an anatomically realistic human right coronary artery.
pubmed:affiliation
Department of Mechanical and Industrial Engineering, University of Toronto, Ontario, Canada.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't