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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2001-4-3
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pubmed:abstractText |
In an analysis of 84 primary-operated breast cancer patients and 11 healthy donors, we found that the bone marrow of most patients contained memory T cells with specificity for tumor-associated antigens. Patients' bone marrow and peripheral blood contained CD8+ T cells that specifically bound HLA/peptide tetramers. In short-term culture with autologous dendritic cells pre-pulsed with tumor lysates, patients' memory T cells from bone marrow (but not peripheral blood) could be specifically reactivated to interferon-gamma-producing and cytotoxic effector cells. A single transfer of restimulated bone-marrow T cells into NOD/SCID mice caused regression of autologous tumor xenotransplants associated with infiltration by human T cells and tumor-cell apoptosis and necrosis. T cells from peripheral blood showed much lower anti-tumor reactivity. Our findings reveal an innate, specific recognition of breast cancer antigens and point to a possible novel cancer therapy using patients' bone-marrow-derived memory T cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1078-8956
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
452-8
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:11283672-Amino Acid Sequence,
pubmed-meshheading:11283672-Animals,
pubmed-meshheading:11283672-Antigens, Neoplasm,
pubmed-meshheading:11283672-Apoptosis,
pubmed-meshheading:11283672-Bone Marrow Transplantation,
pubmed-meshheading:11283672-Breast Neoplasms,
pubmed-meshheading:11283672-Female,
pubmed-meshheading:11283672-HLA-A2 Antigen,
pubmed-meshheading:11283672-Humans,
pubmed-meshheading:11283672-Immunologic Memory,
pubmed-meshheading:11283672-Interferon-gamma,
pubmed-meshheading:11283672-Lymphocyte Activation,
pubmed-meshheading:11283672-Lymphocytes, Tumor-Infiltrating,
pubmed-meshheading:11283672-Mice,
pubmed-meshheading:11283672-Mice, Inbred NOD,
pubmed-meshheading:11283672-Mice, SCID,
pubmed-meshheading:11283672-Mucin-1,
pubmed-meshheading:11283672-Necrosis,
pubmed-meshheading:11283672-Peptide Fragments,
pubmed-meshheading:11283672-Receptor, erbB-2,
pubmed-meshheading:11283672-T-Lymphocytes,
pubmed-meshheading:11283672-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:11283672-Transplantation, Autologous,
pubmed-meshheading:11283672-Transplantation, Heterologous
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pubmed:year |
2001
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pubmed:articleTitle |
Therapy of human tumors in NOD/SCID mice with patient-derived reactivated memory T cells from bone marrow.
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pubmed:affiliation |
Division of Cellular Immunology, Tumor Immunology Program, German Cancer Research Center, Heidelberg, Germany.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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