|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
5
|
|
pubmed:dateCreated |
2001-4-3
|
|
pubmed:abstractText |
Lexitropsins are modular polyamide molecules that are designed to "read" the base sequence of DNA. Lexitropsins constructed of three types of subunits--pyrrole, imidazole and hydroxypyrrole--allow full recognition of DNA base sequences. Structural studies have revealed the atomic basis of this specificity. Theoretical studies have explored the effectiveness of lexitropsins in targeting a given sequence within a genome, and have been used to analyze and improve lexitropsin design.
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|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Apr
|
|
pubmed:issn |
0929-8673
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
8
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
509-16
|
|
pubmed:dateRevised |
2007-2-12
|
|
pubmed:meshHeading |
pubmed-meshheading:11281838-Base Pairing,
pubmed-meshheading:11281838-Crystallography, X-Ray,
pubmed-meshheading:11281838-DNA,
pubmed-meshheading:11281838-Distamycins,
pubmed-meshheading:11281838-Drug Design,
pubmed-meshheading:11281838-Models, Chemical,
pubmed-meshheading:11281838-Models, Molecular,
pubmed-meshheading:11281838-Netropsin
|
|
pubmed:year |
2001
|
|
pubmed:articleTitle |
Sequence recognition of DNA by lexitropsins.
|
|
pubmed:affiliation |
Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA. goodsell@scripps.edu
|
|
pubmed:publicationType |
Journal Article,
Review
|
