Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2001-3-30
pubmed:abstractText
Members of the imidazoquinoline molecule family, including imiquimod and resiquimod (R-848), have potent antiviral and antitumor activities. Imiquimod cream (5%) (Aldara) is currently indicated for treatment of external genital and perianal warts. Previous characterization of these compounds has focused upon their ability to activate monocytes and dendritic cells, but recent studies have shown that resiquimod also stimulates B lymphocytes to proliferate and express an activated phenotype. This suggests that resiquimod could potentially serve as an effective vaccine adjuvant in stimulating a humoral immune response. This study shows that resiquimod mimics effects of the T-dependent CD40 signal in both mouse and human B cell lines. Resiquimod, like CD40, stimulates antibody secretion, cytokine production, protection from apoptosis, and CD80 upregulation. In addition, it shows synergy with signals delivered by the B cell antigen receptor and heightens CD40-mediated B cell activation, demonstrating that resiquimod can enhance antigen-specific responses in B lymphocytes.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Adjuvants, Immunologic, http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal, http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD40, http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD80, http://linkedlifedata.com/resource/pubmed/chemical/Imidazoles, http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin M, http://linkedlifedata.com/resource/pubmed/chemical/Immunologic Factors, http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6, http://linkedlifedata.com/resource/pubmed/chemical/Lipopolysaccharides, http://linkedlifedata.com/resource/pubmed/chemical/R 848, http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, B-Cell, http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0008-8749
pubmed:author
pubmed:copyrightInfo
Copyright 2001 Academic Press.
pubmed:issnType
Print
pubmed:day
25
pubmed:volume
208
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
9-17
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:11277614-Adjuvants, Immunologic, pubmed-meshheading:11277614-Animals, pubmed-meshheading:11277614-Antibodies, Monoclonal, pubmed-meshheading:11277614-Antigens, CD40, pubmed-meshheading:11277614-Antigens, CD80, pubmed-meshheading:11277614-Apoptosis, pubmed-meshheading:11277614-B-Lymphocytes, pubmed-meshheading:11277614-Cell Division, pubmed-meshheading:11277614-Cell Line, pubmed-meshheading:11277614-CpG Islands, pubmed-meshheading:11277614-Drug Synergism, pubmed-meshheading:11277614-Humans, pubmed-meshheading:11277614-Imidazoles, pubmed-meshheading:11277614-Immunoglobulin M, pubmed-meshheading:11277614-Immunologic Factors, pubmed-meshheading:11277614-Interleukin-6, pubmed-meshheading:11277614-Lipopolysaccharides, pubmed-meshheading:11277614-Lymphocyte Activation, pubmed-meshheading:11277614-Mice, pubmed-meshheading:11277614-RNA, Messenger, pubmed-meshheading:11277614-Receptors, Antigen, B-Cell, pubmed-meshheading:11277614-Tumor Necrosis Factor-alpha, pubmed-meshheading:11277614-Up-Regulation
pubmed:year
2001
pubmed:articleTitle
The immune response modifier resiquimod mimics CD40-induced B cell activation.
pubmed:affiliation
Department of Microbiology, VA Medical Center, Iowa City, Iowa 52242, USA. gail-bishop@uiowa.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't