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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2001-3-29
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pubmed:abstractText |
Antigens of pathogenic microbes that mimic autoantigens are thought to be responsible for the activation of autoreactive T cells. Viral infections have been associated with the development of the neuroendocrine autoimmune diseases type 1 diabetes and stiff-man syndrome, but the mechanism is unknown. These diseases share glutamic acid decarboxylase (GAD65) as a major autoantigen. We screened synthetic peptide libraries dedicated to bind to HLA-DR3, which predisposes to both diseases, using clonal CD4(+) T cells reactive to GAD65 isolated from a prediabetic stiff-man syndrome patient. Here we show that these GAD65-specific T cells crossreact with a peptide of the human cytomegalovirus (hCMV) major DNA-binding protein. This peptide was identified after database searching with a recognition pattern that had been deduced from the library studies. Furthermore, we showed that hCMV-derived epitope can be naturally processed by dendritic cells and recognized by GAD65 reactive T cells. Thus, hCMV may be involved in the loss of T cell tolerance to autoantigen GAD65 by a mechanism of molecular mimicry leading to autoimmunity.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/11274421-10330300,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11274421-10679401,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11274421-1309355,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11274421-1697648,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11274421-1901764,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11274421-2174808,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11274421-2566781,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11274421-2664359,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11274421-2898620,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11274421-3281011,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11274421-3323806,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11274421-6105486,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11274421-7665674,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11274421-7847635,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11274421-7934413,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11274421-7962558,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11274421-7963724,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11274421-8145033,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11274421-8207204,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11274421-8574952,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11274421-8772714,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11274421-8968213,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11274421-8994870,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11274421-9084973,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11274421-9130047,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11274421-9294207,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11274421-9521319,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11274421-9558061,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11274421-9624003,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11274421-9645372,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11274421-9662368,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11274421-9761770,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11274421-9780178,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11274421-9802984
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0027-8424
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pubmed:author |
pubmed-author:BehanP OPO,
pubmed-author:ChaudhuriAA,
pubmed-author:DrijfhoutJ WJW,
pubmed-author:FrankenK LKL,
pubmed-author:HiemstraH SHS,
pubmed-author:RoepB OBO,
pubmed-author:SchlootN CNC,
pubmed-author:WillemenS JSJ,
pubmed-author:de VriesR RRR,
pubmed-author:van RoodJ JJJ,
pubmed-author:van VeelenP APA
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pubmed:issnType |
Print
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pubmed:day |
27
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pubmed:volume |
98
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3988-91
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:11274421-Antigens, Viral,
pubmed-meshheading:11274421-Autoantibodies,
pubmed-meshheading:11274421-Autoantigens,
pubmed-meshheading:11274421-Autoimmunity,
pubmed-meshheading:11274421-Cross Reactions,
pubmed-meshheading:11274421-Cytomegalovirus,
pubmed-meshheading:11274421-Epitopes,
pubmed-meshheading:11274421-Glutamate Decarboxylase,
pubmed-meshheading:11274421-Humans,
pubmed-meshheading:11274421-T-Lymphocytes
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pubmed:year |
2001
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pubmed:articleTitle |
Cytomegalovirus in autoimmunity: T cell crossreactivity to viral antigen and autoantigen glutamic acid decarboxylase.
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pubmed:affiliation |
Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, P. O. Box 9600, NL-2300 RC Leiden, The Netherlands.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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