Source:http://linkedlifedata.com/resource/pubmed/id/11260056
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
2001-3-22
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pubmed:abstractText |
We investigated the association of vitamin K status with warfarin sensitivity among 40 orthopaedic patients beginning perioperative algorithm-dosed warfarin. Baseline vitamin K status was assessed using plasma vitamin K-1 and vitamin K-1 2,3 epoxide concentrations, and a questionnaire-based estimation of usual vitamin K intake. Warfarin sensitivity was assessed as the increase in the International Normalized Ratio (INR) after two doses of 5 mg of warfarin and as the 4-d accumulation of under-gamma-carboxylated prothrombin (PIVKA-II), adjusted for warfarin dose requirement. Multivariate models were used to assess vitamin K variables as predictors of warfarin sensitivity. The mean INR increase was 0.53 U and the mean PIVKA-II increase was 771 ng/ml/mg warfarin. Demographic factors were not associated with warfarin response. For each 1 standard deviation (SD) lower value of plasma vitamin K-1, but not the other vitamin K variables, the INR rose 0.24 U (P < or = 0.01). A higher usual vitamin K intake and plasma vitamin K-1, and lower plasma vitamin K-1 2,3 epoxide, were all associated with a lower PIVKA-II increase over 4 d. Respective differences in PIVKA-II accumulation per SD increase of each variable were -165, -218 and 236 ng/ml/mg warfarin (all P < or = 0.05). We concluded that dietary and biochemical measures of vitamin K status were associated with early warfarin sensitivity.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anticoagulants,
http://linkedlifedata.com/resource/pubmed/chemical/Biological Markers,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Precursors,
http://linkedlifedata.com/resource/pubmed/chemical/Prothrombin,
http://linkedlifedata.com/resource/pubmed/chemical/Triglycerides,
http://linkedlifedata.com/resource/pubmed/chemical/Vitamin K,
http://linkedlifedata.com/resource/pubmed/chemical/Vitamin K 1,
http://linkedlifedata.com/resource/pubmed/chemical/Warfarin,
http://linkedlifedata.com/resource/pubmed/chemical/acarboxyprothrombin,
http://linkedlifedata.com/resource/pubmed/chemical/vitamin K1 oxide
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0007-1048
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
112
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
572-7
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:11260056-Aged,
pubmed-meshheading:11260056-Anticoagulants,
pubmed-meshheading:11260056-Biological Markers,
pubmed-meshheading:11260056-Female,
pubmed-meshheading:11260056-Humans,
pubmed-meshheading:11260056-International Normalized Ratio,
pubmed-meshheading:11260056-Linear Models,
pubmed-meshheading:11260056-Male,
pubmed-meshheading:11260056-Middle Aged,
pubmed-meshheading:11260056-Nutritional Status,
pubmed-meshheading:11260056-Preoperative Care,
pubmed-meshheading:11260056-Protein Precursors,
pubmed-meshheading:11260056-Prothrombin,
pubmed-meshheading:11260056-Treatment Outcome,
pubmed-meshheading:11260056-Triglycerides,
pubmed-meshheading:11260056-Vitamin K,
pubmed-meshheading:11260056-Vitamin K 1,
pubmed-meshheading:11260056-Warfarin
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pubmed:year |
2001
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pubmed:articleTitle |
The association of vitamin K status with warfarin sensitivity at the onset of treatment.
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pubmed:affiliation |
Department of Medicine, University of Vermont, 208 South Park Drive, Suite 2, Colchester, VT 05446, USA. mcushman@salus.uvm.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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