Linked Life Data

11259774

Source:http://linkedlifedata.com/resource/pubmed/id/11259774

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
2001-3-22
pubmed:abstractText
Chemoreflex activation with potassium cyanide (KCN, i.v.) produces pressor and bradycardic responses in awake rats in addition to the tachypneic response. In the present study we evaluated the role of the paraventricular nucleus of the hypothalamus (PVN) in the cardiovascular responses to chemoreflex activation in awake rats. Bilateral electrolytic lesion of the PVN was performed 1 day before chemoreflex activation and the results were compared to those obtained with sham-lesioned rats. Bilateral electrolytic lesion of the PVN (n=6) produced a significant reduction in both the magnitude (+51+/-5 vs. +22+/-2 mmHg) and duration (+26+/-5 vs. +6+/-2 s) of the pressor response to chemoreflex activation when compared to sham-lesioned rats (n=10). The bradycardic response to chemoreflex activation in rats with bilateral lesion of the PVN was not significantly different from the response of sham-lesioned rats (-229+/-20 vs. -88+/-76 bpm). Unilateral or partial bilateral lesion of the PVN (n=10) produced no significant changes in the pressor response (+51+/-5 vs. +49+/-3 mmHg), in the duration of the response (+26+/-5 vs. +18+/-3 s) or in the bradycardic response (-229+/-20 vs. -230+/-27 bpm) compared to sham-lesioned rats. The data show that effective bilateral lesion of the PVN produced a significant reduction in the magnitude and duration of the pressor response, indicating that the PVN plays a key role in the processing of the sympathoexcitatory component of the chemoreflex.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
23
pubmed:volume
895
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
167-72
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
2001
pubmed:articleTitle
Involvement of the paraventricular nucleus of the hypothalamus in the pressor response to chemoreflex activation in awake rats.
pubmed:affiliation
Department of Physiology, School of Medicine of Ribeirão Preto, University of São Paulo, 14049-900, Ribeirão Preto, SP, Brazil.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't