Linked Life Data

11256947

Source:http://linkedlifedata.com/resource/pubmed/id/11256947

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
Pt 1
pubmed:dateCreated
2001-3-21
pubmed:abstractText
Polyamines and polyamine analogues have been demonstrated to modulate the transcription of various genes. Spermidine/spermine N(1)-acetyltransferase (SSAT) is transcriptionally regulated through the interaction of at least two trans-acting transcription factors, NF-E2-related factor 2 (Nrf-2) and PMF-1 (polyamine modulated factor-1). Nrf-2 has previously been shown to regulate transcription of other genes through interactions between its C-terminal leucine zipper and the leucine-zipper region of other members of the small Maf protein family (the term "Maf" is derived from MusculoAponeurotic-Fibrosarcoma virus). Here it is demonstrated that the interaction between Nrf-2 and PMF-1 is mediated through the binding of the leucine-zipper region of Nrf-2 and a C-terminal coiled-coil region of PMF-1 that does not contain a leucine zipper. Mutations that interrupt either the leucine zipper of Nrf-2 or the coiled-coil region of PMF-1 are demonstrated to alter the ability of these factors to interact, thus their ability to regulate the transcription of the SSAT gene is lost.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/11256947-10096560, http://linkedlifedata.com/resource/pubmed/commentcorrection/11256947-10419538, http://linkedlifedata.com/resource/pubmed/commentcorrection/11256947-2031185, http://linkedlifedata.com/resource/pubmed/commentcorrection/11256947-2498320, http://linkedlifedata.com/resource/pubmed/commentcorrection/11256947-3128541, http://linkedlifedata.com/resource/pubmed/commentcorrection/11256947-7443525, http://linkedlifedata.com/resource/pubmed/commentcorrection/11256947-7706310, http://linkedlifedata.com/resource/pubmed/commentcorrection/11256947-8107826, http://linkedlifedata.com/resource/pubmed/commentcorrection/11256947-8360194, http://linkedlifedata.com/resource/pubmed/commentcorrection/11256947-8572176, http://linkedlifedata.com/resource/pubmed/commentcorrection/11256947-8573111, http://linkedlifedata.com/resource/pubmed/commentcorrection/11256947-8743703, http://linkedlifedata.com/resource/pubmed/commentcorrection/11256947-9150357, http://linkedlifedata.com/resource/pubmed/commentcorrection/11256947-9195958, http://linkedlifedata.com/resource/pubmed/commentcorrection/11256947-9462700, http://linkedlifedata.com/resource/pubmed/commentcorrection/11256947-9598871, http://linkedlifedata.com/resource/pubmed/commentcorrection/11256947-9852135
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0264-6021
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
355
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
45-9
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2001
pubmed:articleTitle
Characterization of the interaction between the transcription factors human polyamine modulated factor (PMF-1) and NF-E2-related factor 2 (Nrf-2) in the transcriptional regulation of the spermidine/spermine N1-acetyltransferase (SSAT) gene.
pubmed:affiliation
The Johns Hopkins Oncology Center, Bunting-Blaustein Cancer Research Building, Room 551, 1650 Orleans Street, Baltimore, MD 21231, U.S.A.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.