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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2001-3-13
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pubmed:abstractText |
The human T cell leukemia virus-1 (HTLV-1) is a retrovirus that causes adult T cell leukemia (ATL) and neurological disorder, the tropical spastic paraparesis (HAM/TSP). The pathogenesis apparently results from the pleiotropic function of Tax protein, which is a key regulator of viral replication. Tax exerts (a) trans-activation and -repression of transcription of different sets of cellular genes through binding to groups of transcription factors and coactivators, (b) dysregulation of cell cycle through binding to inhibitors of CDK4/6, and (c) inhibition of some tumor suppressor proteins. These effects on a wide variety of cellular targets seem to cooperate in promoting cell proliferation. This is an effective viral strategy to amplify its proviral genome through replication of infected cells; ultimately it results in cell transformation and leukemogenesis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cell Cycle Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP Response...,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Gene Products, tax,
http://linkedlifedata.com/resource/pubmed/chemical/I-kappa B Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Serum Response Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Protein p53
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pubmed:status |
MEDLINE
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pubmed:issn |
0732-0582
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
475-96
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:11244044-Apoptosis,
pubmed-meshheading:11244044-CD4-Positive T-Lymphocytes,
pubmed-meshheading:11244044-Cell Cycle,
pubmed-meshheading:11244044-Cell Cycle Proteins,
pubmed-meshheading:11244044-Cell Division,
pubmed-meshheading:11244044-Cell Transformation, Viral,
pubmed-meshheading:11244044-Cyclic AMP Response Element-Binding Protein,
pubmed-meshheading:11244044-DNA-Binding Proteins,
pubmed-meshheading:11244044-Female,
pubmed-meshheading:11244044-Gene Expression Regulation, Viral,
pubmed-meshheading:11244044-Gene Products, tax,
pubmed-meshheading:11244044-Genes, pX,
pubmed-meshheading:11244044-Human T-lymphotropic virus 1,
pubmed-meshheading:11244044-Humans,
pubmed-meshheading:11244044-I-kappa B Proteins,
pubmed-meshheading:11244044-Leukemia-Lymphoma, Adult T-Cell,
pubmed-meshheading:11244044-Male,
pubmed-meshheading:11244044-Models, Biological,
pubmed-meshheading:11244044-NF-kappa B,
pubmed-meshheading:11244044-Neoplastic Stem Cells,
pubmed-meshheading:11244044-Nuclear Proteins,
pubmed-meshheading:11244044-Serum Response Factor,
pubmed-meshheading:11244044-Trans-Activators,
pubmed-meshheading:11244044-Transcriptional Activation,
pubmed-meshheading:11244044-Tumor Suppressor Protein p53,
pubmed-meshheading:11244044-Virus Replication
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pubmed:year |
2001
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pubmed:articleTitle |
Multiple viral strategies of HTLV-1 for dysregulation of cell growth control.
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pubmed:affiliation |
Banyu Tsukuba Research Institute, Tsukuba, Ibaraki 300-2611, Japan. yoshimx@banyu.co.jp
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pubmed:publicationType |
Journal Article,
Review
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