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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2001-3-12
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pubmed:abstractText |
Estrogen, a steroid hormone, regulates reproduction and has been implicated in several diseases. We performed a genome-wide scan using multipoint linkage analysis implemented in a general pedigree-based variance component approach to identify genes with measurable effects on variation in estrogen levels in baboons. A microsatellite polymorphism, D20S171, located on human chromosome 20q13.11, showed strong evidence of linkage with a LOD score of 3.06 (P = 0.00009). This region contains several potential candidate genes including melanocortin 3 receptor (MC3R), cytochrome P-450 subfamily XXIV (CYP24), and breast carcinoma amplified sequence (BCAS1). This is the first evidence of a quantitative trait locus with a significant effect on estrogen.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1531-2267
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
8
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
75-80
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:11242591-Aging,
pubmed-meshheading:11242591-Animals,
pubmed-meshheading:11242591-Body Weight,
pubmed-meshheading:11242591-Chromosome Mapping,
pubmed-meshheading:11242591-Chromosomes, Human, Pair 20,
pubmed-meshheading:11242591-Estradiol,
pubmed-meshheading:11242591-Estrogens,
pubmed-meshheading:11242591-Female,
pubmed-meshheading:11242591-Genotype,
pubmed-meshheading:11242591-Humans,
pubmed-meshheading:11242591-Likelihood Functions,
pubmed-meshheading:11242591-Lod Score,
pubmed-meshheading:11242591-Male,
pubmed-meshheading:11242591-Menstrual Cycle,
pubmed-meshheading:11242591-Microsatellite Repeats,
pubmed-meshheading:11242591-Models, Genetic,
pubmed-meshheading:11242591-Papio,
pubmed-meshheading:11242591-Pedigree,
pubmed-meshheading:11242591-Polymorphism, Genetic,
pubmed-meshheading:11242591-Quantitative Trait, Heritable,
pubmed-meshheading:11242591-Radioimmunoassay,
pubmed-meshheading:11242591-Sequence Homology, Nucleic Acid,
pubmed-meshheading:11242591-Sex Characteristics
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pubmed:year |
2001
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pubmed:articleTitle |
A quantitative trait locus influencing estrogen levels maps to a region homologous to human chromosome 20.
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pubmed:affiliation |
Departments of Genetics, Physiology and Medicine, Southwest Foundation for Biomedical Research San Antonio, Texas 78245-0549, USA. lmartin@darwin.sfbr.org
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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