Source:http://linkedlifedata.com/resource/pubmed/id/11237825
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
|
| pubmed:dateCreated |
2001-3-12
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| pubmed:abstractText |
To assess the effect of treatment of vaginal infections on vaginal shedding of cell-free human immunodeficiency virus type 1 (HIV-1) and HIV-1-infected cells, HIV-1-seropositive women were examined before and after treatment of Candida vulvovaginitis, Trichomonas vaginitis, and bacterial vaginosis. For Candida (n=98), vaginal HIV-1 RNA decreased from 3.36 to 2.86 log(10) copies/swab (P<.001), as did the prevalence of HIV-1 DNA (36% to 17%; odds ratio [OR], 2.8; 95% confidence interval [CI], 1.3-6.5). For Trichomonas vaginitis (n=55), HIV-1 RNA decreased from 3.67 to 3.05 log(10) copies/swab (P<.001), but the prevalence of HIV-1 DNA remained unchanged (22%-25%; OR, 0.8; 95% CI, 0.3-2.2). For bacterial vaginosis (n=73), neither the shedding of HIV-1 RNA (from 3.11 to 2.90 log(10) copies/swab; P=.14) nor the prevalence of DNA (from 21% to 23%; OR, 0.8; 95% CI, 0.3-2.0) changed. Vaginal HIV-1 decreased 3.2- and 4.2-fold after treating Candida and Trichomonas, respectively. These data suggest that HIV-1 transmission intervention strategies that incorporate diagnosis and treatment of these prevalent infections warrant evaluation.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Bacterial Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Antitrichomonal Agents,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Metronidazole,
http://linkedlifedata.com/resource/pubmed/chemical/Nystatin,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Viral
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| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0022-1899
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
183
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1017-22
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| pubmed:dateRevised |
2007-11-14
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| pubmed:meshHeading |
pubmed-meshheading:11237825-Adult,
pubmed-meshheading:11237825-Anti-Bacterial Agents,
pubmed-meshheading:11237825-Antitrichomonal Agents,
pubmed-meshheading:11237825-Candidiasis,
pubmed-meshheading:11237825-DNA, Viral,
pubmed-meshheading:11237825-Down-Regulation,
pubmed-meshheading:11237825-Female,
pubmed-meshheading:11237825-HIV Infections,
pubmed-meshheading:11237825-HIV Seropositivity,
pubmed-meshheading:11237825-HIV-1,
pubmed-meshheading:11237825-Humans,
pubmed-meshheading:11237825-Metronidazole,
pubmed-meshheading:11237825-Nystatin,
pubmed-meshheading:11237825-Odds Ratio,
pubmed-meshheading:11237825-Prospective Studies,
pubmed-meshheading:11237825-RNA, Viral,
pubmed-meshheading:11237825-Trichomonas Vaginitis,
pubmed-meshheading:11237825-Vagina,
pubmed-meshheading:11237825-Vaginitis,
pubmed-meshheading:11237825-Vaginosis, Bacterial,
pubmed-meshheading:11237825-Virus Shedding
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| pubmed:year |
2001
|
| pubmed:articleTitle |
The effect of treatment of vaginal infections on shedding of human immunodeficiency virus type 1.
|
| pubmed:affiliation |
Departments of Medicine and Epidemiology, Division of Infectious Diseases, University of Washington, Seattle, WA 98104-2499, USA. chiaw@u.washington.edu
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| pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|