| pubmed-article:11231976 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11231976 | lifeskim:mentions | umls-concept:C0071011 | lld:lifeskim |
| pubmed-article:11231976 | lifeskim:mentions | umls-concept:C0004153 | lld:lifeskim |
| pubmed-article:11231976 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:11231976 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:11231976 | lifeskim:mentions | umls-concept:C0232970 | lld:lifeskim |
| pubmed-article:11231976 | lifeskim:mentions | umls-concept:C0449258 | lld:lifeskim |
| pubmed-article:11231976 | lifeskim:mentions | umls-concept:C1707455 | lld:lifeskim |
| pubmed-article:11231976 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:11231976 | lifeskim:mentions | umls-concept:C2756587 | lld:lifeskim |
| pubmed-article:11231976 | lifeskim:mentions | umls-concept:C1136013 | lld:lifeskim |
| pubmed-article:11231976 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:11231976 | pubmed:dateCreated | 2001-3-14 | lld:pubmed |
| pubmed-article:11231976 | pubmed:abstractText | Experimental evidence was sought concerning whether soy phytoestrogens (SPEs) inhibit postmenopausal atherosclerosis progression/extent and, if so, their effectiveness relative to traditional estrogen replacement therapy. Premenopausal cynomolgus monkeys were fed a moderately atherogenic diet (26 months) to induce atherosclerosis. After ovariectomy, the moderately atherogenic diet was continued, and they were treated (36 months) with a control diet (soy protein depleted of SPEs), a diet containing SPEs in soy protein isolate, or a diet containing SPE-depleted soy protein with conjugated equine estrogens (CEE; Premarin) added. SPE effects on plasma lipids were better than those of CEE (higher high density lipoprotein cholesterol and no increase in triglyceride). Relative to the control group, CEE treatment inhibited (P = 0.0001), and SPE treatment partially inhibited (P = 0.10) the progression of atherosclerosis (common iliac artery atherosclerosis before and after treatment). CEE-treated monkeys had much less coronary artery atherosclerosis than the controls (P = 0.0002), whereas SPE-treated monkeys were intermediate in lesion extent between the controls and the CEE-treated animals (P = 0.02). Both CEE and SPE significantly reduced the extent of common carotid and internal carotid artery atherosclerosis, and the two treatment groups were not significantly different. | lld:pubmed |
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| pubmed-article:11231976 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:11231976 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:11231976 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11231976 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:11231976 | pubmed:issn | 0021-972X | lld:pubmed |
| pubmed-article:11231976 | pubmed:author | pubmed-author:ClarksonT BTB | lld:pubmed |
| pubmed-article:11231976 | pubmed:author | pubmed-author:MorganT MTM | lld:pubmed |
| pubmed-article:11231976 | pubmed:author | pubmed-author:AnthonyM SMS | lld:pubmed |
| pubmed-article:11231976 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11231976 | pubmed:volume | 86 | lld:pubmed |
| pubmed-article:11231976 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11231976 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11231976 | pubmed:pagination | 41-7 | lld:pubmed |
| pubmed-article:11231976 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:11231976 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11231976 | pubmed:articleTitle | Inhibition of postmenopausal atherosclerosis progression: a comparison of the effects of conjugated equine estrogens and soy phytoestrogens. | lld:pubmed |
| pubmed-article:11231976 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11231976 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:11231976 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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