Source:http://linkedlifedata.com/resource/pubmed/id/11231976
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2001-3-14
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| pubmed:abstractText |
Experimental evidence was sought concerning whether soy phytoestrogens (SPEs) inhibit postmenopausal atherosclerosis progression/extent and, if so, their effectiveness relative to traditional estrogen replacement therapy. Premenopausal cynomolgus monkeys were fed a moderately atherogenic diet (26 months) to induce atherosclerosis. After ovariectomy, the moderately atherogenic diet was continued, and they were treated (36 months) with a control diet (soy protein depleted of SPEs), a diet containing SPEs in soy protein isolate, or a diet containing SPE-depleted soy protein with conjugated equine estrogens (CEE; Premarin) added. SPE effects on plasma lipids were better than those of CEE (higher high density lipoprotein cholesterol and no increase in triglyceride). Relative to the control group, CEE treatment inhibited (P = 0.0001), and SPE treatment partially inhibited (P = 0.10) the progression of atherosclerosis (common iliac artery atherosclerosis before and after treatment). CEE-treated monkeys had much less coronary artery atherosclerosis than the controls (P = 0.0002), whereas SPE-treated monkeys were intermediate in lesion extent between the controls and the CEE-treated animals (P = 0.02). Both CEE and SPE significantly reduced the extent of common carotid and internal carotid artery atherosclerosis, and the two treatment groups were not significantly different.
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| pubmed:grant | |
| pubmed:commentsCorrections | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Estrogens, Conjugated (USP),
http://linkedlifedata.com/resource/pubmed/chemical/Estrogens, Non-Steroidal,
http://linkedlifedata.com/resource/pubmed/chemical/Hormones,
http://linkedlifedata.com/resource/pubmed/chemical/Isoflavones,
http://linkedlifedata.com/resource/pubmed/chemical/Lipids,
http://linkedlifedata.com/resource/pubmed/chemical/Lipoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Phytoestrogens,
http://linkedlifedata.com/resource/pubmed/chemical/Plant Preparations,
http://linkedlifedata.com/resource/pubmed/chemical/Soybean Proteins
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jan
|
| pubmed:issn |
0021-972X
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
86
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
41-7
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| pubmed:dateRevised |
2007-11-15
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| pubmed:meshHeading |
pubmed-meshheading:11231976-Animals,
pubmed-meshheading:11231976-Arteriosclerosis,
pubmed-meshheading:11231976-Carotid Artery Diseases,
pubmed-meshheading:11231976-Coronary Artery Disease,
pubmed-meshheading:11231976-Disease Progression,
pubmed-meshheading:11231976-Estrogens, Conjugated (USP),
pubmed-meshheading:11231976-Estrogens, Non-Steroidal,
pubmed-meshheading:11231976-Female,
pubmed-meshheading:11231976-Hormones,
pubmed-meshheading:11231976-Horses,
pubmed-meshheading:11231976-Isoflavones,
pubmed-meshheading:11231976-Lipids,
pubmed-meshheading:11231976-Lipoproteins,
pubmed-meshheading:11231976-Macaca fascicularis,
pubmed-meshheading:11231976-Phytoestrogens,
pubmed-meshheading:11231976-Plant Preparations,
pubmed-meshheading:11231976-Postmenopause,
pubmed-meshheading:11231976-Soybean Proteins
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| pubmed:year |
2001
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| pubmed:articleTitle |
Inhibition of postmenopausal atherosclerosis progression: a comparison of the effects of conjugated equine estrogens and soy phytoestrogens.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
|