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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1975-7-1
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pubmed:abstractText |
6-N-Hydroxylaminopurine riboside (HAPR) was studied in man because of its therapeutic activity in several transplanted animal neoplasms. It was not cross-resistant to other antimetabolites useful in the treatment of human neoplasia. HAPR produced marked hemolytic anemia at doses far below those that might have produced any cytotoxic or therapeutic effect. There was evidence of hemolysis at total doses as low as 0.5 mg/kg given intravenously. For man, HAPR is one of the most active hemolytic drugs.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0009-9236
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
57-65
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1122670-Adenosine,
pubmed-meshheading:1122670-Adult,
pubmed-meshheading:1122670-Bilirubin,
pubmed-meshheading:1122670-Blood Cell Count,
pubmed-meshheading:1122670-Breast Neoplasms,
pubmed-meshheading:1122670-Dipyridamole,
pubmed-meshheading:1122670-Erythrocytes,
pubmed-meshheading:1122670-Female,
pubmed-meshheading:1122670-Hemoglobins,
pubmed-meshheading:1122670-Hemolysis,
pubmed-meshheading:1122670-Humans,
pubmed-meshheading:1122670-Hydroxylamines,
pubmed-meshheading:1122670-Male,
pubmed-meshheading:1122670-Melanoma,
pubmed-meshheading:1122670-Middle Aged,
pubmed-meshheading:1122670-Neoplasm Metastasis,
pubmed-meshheading:1122670-Neoplasms,
pubmed-meshheading:1122670-Purines,
pubmed-meshheading:1122670-Rectal Neoplasms,
pubmed-meshheading:1122670-Reticulocytes,
pubmed-meshheading:1122670-Time Factors
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pubmed:year |
1975
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pubmed:articleTitle |
Hemolysis induced by 6-N-hydroxylaminopurine riboside, an adenosine analogue.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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