Source:http://linkedlifedata.com/resource/pubmed/id/11226709
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2001-3-6
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| pubmed:abstractText |
In the present study we investigated the effects of bilateral microinjection into the lateral commissural nucleus tractus solitarius (NTS) of 2-methyl-5-HT, a 5-HT3 receptor agonist, on the bradycardic response of the von Bezold-Jarisch reflex of awake rats. We evaluated mainly the bradycardic response because in previous studies we documented that the hypotensive response of the von-Bezold-Jarisch reflex in awake rats is secondary to the intense bradycardic response. The Bezold-Jarisch reflex was activated by intravenous injection of serotonin (8 microg/kg) in awake rats before and 1, 3, 10, 20 and 60 min after bilateral microinjection of 2-methyl-5-HT (5 nmol/50 nl, n = 8) into the NTS. Microinjections of 2-methyl-5-HT into the NTS produced a significant increase in basal mean arterial pressure [(MAP), 97 +/- 4 vs. 114 +/- 4 mmHg), no changes in basal heart rate and a significant reduction in bradycardic (-78 +/- 19; -94 +/- 24 and -107 +/- 21 bpm) and hypotensive (-16 +/- 4; -10 +/- 5 and -17 +/- 4 mmHg) responses to activation of the von Bezold-Jarisch reflex at 3, 10 and 20 min, respectively, when compared with the control value (-231 +/- 13 bpm and -43 +/- 4 mmHg). The data of the present study suggest that serotonin acting on 5-HT3 receptors in the NTS may play an important inhibitory neuromodulatory role in the bradycardic response to activation of the von Bezold-Jarisch reflex.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/2-methyl-5-HT,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Serotonin,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Serotonin, 5-HT3,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin Receptor Agonists
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jan
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| pubmed:issn |
0361-9230
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:day |
1
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| pubmed:volume |
54
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
7-11
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| pubmed:dateRevised |
2010-11-18
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| pubmed:meshHeading |
pubmed-meshheading:11226709-Analysis of Variance,
pubmed-meshheading:11226709-Animals,
pubmed-meshheading:11226709-Arousal,
pubmed-meshheading:11226709-Blood Pressure,
pubmed-meshheading:11226709-Bradycardia,
pubmed-meshheading:11226709-Heart Rate,
pubmed-meshheading:11226709-Male,
pubmed-meshheading:11226709-Microinjections,
pubmed-meshheading:11226709-Nerve Fibers,
pubmed-meshheading:11226709-Neural Inhibition,
pubmed-meshheading:11226709-Parasympathetic Nervous System,
pubmed-meshheading:11226709-Rats,
pubmed-meshheading:11226709-Rats, Wistar,
pubmed-meshheading:11226709-Receptors, Serotonin,
pubmed-meshheading:11226709-Receptors, Serotonin, 5-HT3,
pubmed-meshheading:11226709-Reflex, Abnormal,
pubmed-meshheading:11226709-Serotonin,
pubmed-meshheading:11226709-Serotonin Receptor Agonists,
pubmed-meshheading:11226709-Solitary Nucleus,
pubmed-meshheading:11226709-Sympathetic Nervous System,
pubmed-meshheading:11226709-Synaptic Transmission
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| pubmed:year |
2001
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| pubmed:articleTitle |
Microinjection of a 5-HT3 receptor agonist into the NTS of awake rats inhibits the bradycardic response to activation of the von Bezold-Jarisch reflex.
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| pubmed:affiliation |
Department of Physiology, School of Medicine of Ribeirão Preto, University of São Paulo, São Paulo, Ribeirão Preto, Brazil.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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