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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
2001-3-6
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pubmed:abstractText |
Four protein fragments which span the entire hemagglutinin-neuraminidase protein (HN) of mumps virus were expressed in HeLa cells and cell extracts were tested for their capability to induce neutralizing antibodies in mice. Fragment HN3 (aa 213-372) was able to induce the production of hemagglutination-inhibiting and neutralizing antibodies. When a subfragment of HN3, the synthetic peptide NSTLGVKSAREF (aa 329-340 of HN) was used for immunization, hemagglutination-inhibiting and neutralizing antibodies against mumps wild type virus but not against the Urabe Am9 vaccine virus were raised. The peptide could, therefore, contain a new epitope, which may be critical for protective host humoral immune response.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Epitopes, B-Lymphocyte,
http://linkedlifedata.com/resource/pubmed/chemical/HN Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Mumps Vaccine,
http://linkedlifedata.com/resource/pubmed/chemical/Neuraminidase,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0168-1702
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
74
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
133-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11226581-Animals,
pubmed-meshheading:11226581-Antibodies, Monoclonal,
pubmed-meshheading:11226581-Antibodies, Viral,
pubmed-meshheading:11226581-Antigens, Viral,
pubmed-meshheading:11226581-Cell Line,
pubmed-meshheading:11226581-Cercopithecus aethiops,
pubmed-meshheading:11226581-Epitope Mapping,
pubmed-meshheading:11226581-Epitopes, B-Lymphocyte,
pubmed-meshheading:11226581-Female,
pubmed-meshheading:11226581-HN Protein,
pubmed-meshheading:11226581-HeLa Cells,
pubmed-meshheading:11226581-Humans,
pubmed-meshheading:11226581-Mice,
pubmed-meshheading:11226581-Mice, Inbred BALB C,
pubmed-meshheading:11226581-Mumps Vaccine,
pubmed-meshheading:11226581-Mumps virus,
pubmed-meshheading:11226581-Neuraminidase,
pubmed-meshheading:11226581-Neutralization Tests,
pubmed-meshheading:11226581-Peptides,
pubmed-meshheading:11226581-Vero Cells
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pubmed:year |
2001
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pubmed:articleTitle |
Localization of a new neutralizing epitope on the mumps virus hemagglutinin-neuraminidase protein.
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pubmed:affiliation |
Department of Molecular Biology, Section of Microbiology, University of Siena, Via Laterina, 8-53100, Siena, Italy. cusi@unisi.it
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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