Source:http://linkedlifedata.com/resource/pubmed/id/11226401
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2-3
|
| pubmed:dateCreated |
2001-3-6
|
| pubmed:abstractText |
Experiments were undertaken, using laser-Doppler flowmetry, to determine the nature of adrenoceptors mediating sympathetic nerve evoked nasal vasoconstrictor responses in anesthetized rats. Presence of sympathetic tone was confirmed by a large (330%) increase of nasal blood flow following section of the ipsilateral preganglionic cervical sympathetic nerve. Electrical nerve stimulation produced reproducible, frequency-related nasal vasoconstrictor responses with near maximal response, observed at less than 10 Hz. Evoked nasal vasoconstrictor responses were largely blocked with intravenous treatment with the non-selective alpha-adrenoceptor antagonists, phentolamine (5 mg kg(-1)) and phenoxybenzamine (2 mg kg(-1)), as well as with the selective alpha(1)-adrenoceptor antagonist, prazosin (300 microg kg(-1)). alpha(2)-Adrenoceptor antagonism with rauwolscine (500 microg kg(-1)) potentiated neurally evoked nasal vasoconstriction. Neither atropine (1 mg kg(-1)) nor propranolol (1 mg kg(-1)) altered the evoked responses. Rats with intact cervical sympathetic nerves responded to rauwolscine with a modest constriction. Subsequent prazosin administration produced an increase of nasal blood flow of approximately 275%. These results suggest that the nasal vasculature of the rat is under intense sympathetic tone and that the resulting neurogenic vasoconstriction is mediated exclusively by activation of alpha(1)-adrenoceptors.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic alpha-Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Norepinephrine,
http://linkedlifedata.com/resource/pubmed/chemical/Phenoxybenzamine,
http://linkedlifedata.com/resource/pubmed/chemical/Phentolamine,
http://linkedlifedata.com/resource/pubmed/chemical/Prazosin,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, alpha-1,
http://linkedlifedata.com/resource/pubmed/chemical/Yohimbine
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0014-2999
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
16
|
| pubmed:volume |
413
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
255-62
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:11226401-Adrenergic Fibers,
pubmed-meshheading:11226401-Adrenergic alpha-Antagonists,
pubmed-meshheading:11226401-Animals,
pubmed-meshheading:11226401-Electric Stimulation,
pubmed-meshheading:11226401-Ganglia, Sympathetic,
pubmed-meshheading:11226401-Laser-Doppler Flowmetry,
pubmed-meshheading:11226401-Male,
pubmed-meshheading:11226401-Nasal Cavity,
pubmed-meshheading:11226401-Nasal Mucosa,
pubmed-meshheading:11226401-Norepinephrine,
pubmed-meshheading:11226401-Phenoxybenzamine,
pubmed-meshheading:11226401-Phentolamine,
pubmed-meshheading:11226401-Prazosin,
pubmed-meshheading:11226401-Rats,
pubmed-meshheading:11226401-Rats, Sprague-Dawley,
pubmed-meshheading:11226401-Receptors, Adrenergic, alpha-1,
pubmed-meshheading:11226401-Vasoconstriction,
pubmed-meshheading:11226401-Yohimbine
|
| pubmed:year |
2001
|
| pubmed:articleTitle |
Sympathetic control of nasal blood flow in the rat mediated by alpha(1)-adrenoceptors.
|
| pubmed:affiliation |
Department of Biosciences, Teikyo University of Science and Technology, Yamanashi, Japan
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|