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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2001-2-23
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pubmed:abstractText |
L-buthionine sulfoximine (BSO) inhibits glutathione synthesis and may modulate tumor resistance to some alkylating agents, but it has not been proven effective in the treatment of intracranial neoplasms. To evaluate this drug for the treatment of brain tumors, we studied the use of BSO for potentiating the antineoplastic effect of 4-hydroxyperoxycyclophosphamide (4-HC) in the rat 9L glioma model.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0148-396X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
48
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
392-400
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:11220384-Animals,
pubmed-meshheading:11220384-Antimetabolites, Antineoplastic,
pubmed-meshheading:11220384-Antineoplastic Agents,
pubmed-meshheading:11220384-Brain,
pubmed-meshheading:11220384-Brain Neoplasms,
pubmed-meshheading:11220384-Buthionine Sulfoximine,
pubmed-meshheading:11220384-Cyclophosphamide,
pubmed-meshheading:11220384-Drug Combinations,
pubmed-meshheading:11220384-Drug Implants,
pubmed-meshheading:11220384-Drug Synergism,
pubmed-meshheading:11220384-Glioma,
pubmed-meshheading:11220384-Glutathione,
pubmed-meshheading:11220384-Injections, Intraperitoneal,
pubmed-meshheading:11220384-Liver,
pubmed-meshheading:11220384-Male,
pubmed-meshheading:11220384-Rats,
pubmed-meshheading:11220384-Rats, Inbred F344,
pubmed-meshheading:11220384-Reference Values,
pubmed-meshheading:11220384-Survival Analysis
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pubmed:year |
2001
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pubmed:articleTitle |
L-buthionine sulfoximine potentiates the antitumor effect of 4-hydroperoxycyclophosphamide when administered locally in a rat glioma model.
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pubmed:affiliation |
Department of Neurological Surgery, Johns Hopkins Hospital and School of Medicine, Baltimore, Maryland, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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