Source:http://linkedlifedata.com/resource/pubmed/id/11219455
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
2001-2-21
|
| pubmed:abstractText |
The effects of isoproterenol (ISO, a non-selective beta-agonist), terbutaline (TER, a selective beta2-agonist), CL316243 (CL, a selective beta3-agonist), and epinephrine (EPI, beta- and alpha2-agonist) on in situ lipolytic response of s.c. adipose tissue were investigated in vivo, using a microdialysis method to measure glycerol release, in 12 adult nonlactating and ovariectomized, underfed Lacaune ewes. All the adrenergic compounds were perfused for 120 min at 10(-6), 10(-5), and 10(-4) M. They had no lipolytic effect at 10(-6) M. Isoproterenol and EPI at 10(-5) and 10(-4) M enhanced, in the same way, maximal response and area under the concentration curve (AUC) of dialysate glycerol, thus suggesting that involvement of alpha2-adrenoceptors in the control of in situ lipolysis is of minor importance in underfed ewes. Terbutaline had only a slight lipolytic effect at 10(-5) M. This low effect could be due to a lower affinity of TER than of ISO for the beta2-adrenoceptors. The beta3-agonist, CL, had no lipolytic effect whatever the concentration perfused. Further studies are needed to prove the putative presence of beta3-adrenoceptors and their possible role in the ovine adipose tissue.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic beta-Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Blood Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Epinephrine,
http://linkedlifedata.com/resource/pubmed/chemical/Fatty Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Glycerol,
http://linkedlifedata.com/resource/pubmed/chemical/Isoproterenol,
http://linkedlifedata.com/resource/pubmed/chemical/Lactic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, beta,
http://linkedlifedata.com/resource/pubmed/chemical/Terbutaline
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0021-8812
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
79
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
453-62
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:11219455-Adipose Tissue,
pubmed-meshheading:11219455-Adrenergic beta-Agonists,
pubmed-meshheading:11219455-Animals,
pubmed-meshheading:11219455-Area Under Curve,
pubmed-meshheading:11219455-Blood Glucose,
pubmed-meshheading:11219455-Cross-Over Studies,
pubmed-meshheading:11219455-Epinephrine,
pubmed-meshheading:11219455-Extracellular Space,
pubmed-meshheading:11219455-Fatty Acids,
pubmed-meshheading:11219455-Female,
pubmed-meshheading:11219455-Food Deprivation,
pubmed-meshheading:11219455-Glycerol,
pubmed-meshheading:11219455-Isoproterenol,
pubmed-meshheading:11219455-Lactic Acid,
pubmed-meshheading:11219455-Lipolysis,
pubmed-meshheading:11219455-Microdialysis,
pubmed-meshheading:11219455-Receptors, Adrenergic, beta,
pubmed-meshheading:11219455-Sheep,
pubmed-meshheading:11219455-Terbutaline
|
| pubmed:year |
2001
|
| pubmed:articleTitle |
Effects of the perfusion of beta-, beta2-, or beta3-adrenergic agonists or epinephrine on in situ adipose tissue lipolysis measured by microdialysis in underfed ewes.
|
| pubmed:affiliation |
Adipose Tissue and Milk Lipids Team, Herbivore Research Unit, INRA, Theix, Champanelle, France.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|