Linked Life Data

11213288

Source:http://linkedlifedata.com/resource/pubmed/id/11213288

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2001-2-12
pubmed:abstractText
The discovery of RWJ-54428 (MC-02,479), a new cephalosporin displaying promising activity against sensitive and resistant Gram-positive bacteria, is described. Progressive structural modification from the previously reported 3-phenylthiocephem MC-02,331 afforded an overall increase in potency against MRSA while retaining other key properties such as acceptable solubility and serum binding. Evaluation of the in vitro potency and in vivo efficacy of a series of closely related compounds resulted in selection of RWJ-54428 (MC-02,479) for further studies.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0021-8820
pubmed:author
pubmed:issnType
Print
pubmed:volume
53
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1272-81
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
Discovery of RWJ-54428 (MC-02,479), a new cephalosporin active against resistant gram-positive bacteria.
pubmed:affiliation
Microcide Pharmaceuticals, Inc., Mountain View, California 94043, USA.
pubmed:publicationType
Journal Article