Source:http://linkedlifedata.com/resource/pubmed/id/11208530
Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
|
pubmed:dateCreated |
2001-3-6
|
pubmed:abstractText |
Interleukin-6 (IL-6) is produced within multiple tissues and can be readily detected in the circulation in resuscitated hemorrhagic shock (HS). Instillation of IL-6 into lungs of normal rats induces polymorphonuclear neutrophilic granulocyte (PMN) infiltration and lung damage, while infusion of IL-6 into the systemic circulation of rats during resuscitation from HS reduces PMN recruitment and lung injury. The current study was designed to determine whether or not IL-6 makes an essential contribution to postresuscitation inflammation and which of the two effects of IL-6, its local proinflammatory effect or its systemic anti-inflammatory effect, is dominant in HS. Wild-type and IL-6-deficient mice were subjected to HS followed by resuscitation and death 4 h later. IL-6-deficient mice subjected to HS did not demonstrate any features of postresuscitation inflammation observed in wild-type mice, including increased PMN infiltration into the lungs, increased alveolar cross-sectional surface area, increased PMN infiltration into the liver, increased liver necrosis, increased signal transducer and activator of transcription 3 activation, and increased nuclear factor-kappaB activity. These findings indicate that IL-6 is an essential component of the postresuscitation inflammatory cascade in HS and that the local proinflammatory effects of IL-6 on PMN infiltration and organ damage in HS dominate over the anti-inflammatory effects of systemic IL-6.
|
pubmed:grant | |
pubmed:commentsCorrections | |
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/STAT3 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Stat3 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators
|
pubmed:status |
MEDLINE
|
pubmed:month |
Feb
|
pubmed:issn |
0363-6143
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
280
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
C343-51
|
pubmed:dateRevised |
2007-11-14
|
pubmed:meshHeading |
pubmed-meshheading:11208530-Animals,
pubmed-meshheading:11208530-DNA-Binding Proteins,
pubmed-meshheading:11208530-Inflammation,
pubmed-meshheading:11208530-Interleukin-6,
pubmed-meshheading:11208530-Liver,
pubmed-meshheading:11208530-Lung,
pubmed-meshheading:11208530-Mice,
pubmed-meshheading:11208530-Mice, Inbred C57BL,
pubmed-meshheading:11208530-NF-kappa B,
pubmed-meshheading:11208530-Necrosis,
pubmed-meshheading:11208530-Neutrophils,
pubmed-meshheading:11208530-Resuscitation,
pubmed-meshheading:11208530-STAT3 Transcription Factor,
pubmed-meshheading:11208530-Shock, Hemorrhagic,
pubmed-meshheading:11208530-Signal Transduction,
pubmed-meshheading:11208530-Trans-Activators
|
pubmed:year |
2001
|
pubmed:articleTitle |
Essential role for IL-6 in postresuscitation inflammation in hemorrhagic shock.
|
pubmed:affiliation |
Section of Infectious Diseases, Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA.
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|