| pubmed-article:11207662 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11207662 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:11207662 | lifeskim:mentions | umls-concept:C0012655 | lld:lifeskim |
| pubmed-article:11207662 | lifeskim:mentions | umls-concept:C0040421 | lld:lifeskim |
| pubmed-article:11207662 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:11207662 | lifeskim:mentions | umls-concept:C0017661 | lld:lifeskim |
| pubmed-article:11207662 | lifeskim:mentions | umls-concept:C0007584 | lld:lifeskim |
| pubmed-article:11207662 | lifeskim:mentions | umls-concept:C0442805 | lld:lifeskim |
| pubmed-article:11207662 | lifeskim:mentions | umls-concept:C0392756 | lld:lifeskim |
| pubmed-article:11207662 | lifeskim:mentions | umls-concept:C0205099 | lld:lifeskim |
| pubmed-article:11207662 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:11207662 | pubmed:dateCreated | 2001-3-14 | lld:pubmed |
| pubmed-article:11207662 | pubmed:abstractText | IgAN is a common form of primary glomerulonephritis and also a disease of tonsillar focal infection. The comprehensive mechanism underlying this disease remains to be defined. To better understand its pathogenesis, we investigated tonsillar CD5+ B cells (B-1 cells) with respect to IgA synthesis. Germinal centre (GC) B cells were isolated from the tonsils of IgAN patients and the number of B-1 cells in the GC determined by flow cytometry. GC B-1 and B-2 (CD5- B) cells were purified by cell sorter, the cells were incubated with agonist anti-CD40 MoAb and the ability for antibody production by B-1 and B-2 cells determined by ELISPOT assay. GC B-1 cells and B-2 cells were incubated with agonist anti-Fas MoAb, and apoptosis in GC B-1 cells and B-2 cells was analysed by flow cytometry. Although B-1 cells do not usually take part in the GC reaction, an increase in B-1 cell numbers was observed in the GC of tonsils from IgAN patients. These B-1 cells were likely IgA1 antibody-producing cells, since the prominent IgA subclass in IgAN is generally considered to be IgA1. Although Fas-dependent apoptosis is essential for the elimination of activated B cells, these B-1 cells showed a reduced susceptibility to Fas-mediated apoptosis. It is conceivable that activated B-1 cells may survive in the GC due to impaired apoptosis and thus produce abnormal antibodies. These findings suggest that the immune responses of B-1 cells in the tonsillar GC could thus have an impact on the pathogenesis of IgAN. | lld:pubmed |
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| pubmed-article:11207662 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11207662 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11207662 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11207662 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11207662 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11207662 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:11207662 | pubmed:issn | 0009-9104 | lld:pubmed |
| pubmed-article:11207662 | pubmed:author | pubmed-author:SuzukiMM | lld:pubmed |
| pubmed-article:11207662 | pubmed:author | pubmed-author:AritaMM | lld:pubmed |
| pubmed-article:11207662 | pubmed:author | pubmed-author:MogiGG | lld:pubmed |
| pubmed-article:11207662 | pubmed:author | pubmed-author:KodamaSS | lld:pubmed |
| pubmed-article:11207662 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11207662 | pubmed:volume | 123 | lld:pubmed |
| pubmed-article:11207662 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11207662 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11207662 | pubmed:pagination | 301-8 | lld:pubmed |
| pubmed-article:11207662 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:11207662 | pubmed:meshHeading | pubmed-meshheading:11207662... | lld:pubmed |
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| pubmed-article:11207662 | pubmed:meshHeading | pubmed-meshheading:11207662... | lld:pubmed |
| pubmed-article:11207662 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11207662 | pubmed:articleTitle | Increase in tonsillar germinal centre B-1 cell numbers in IgA nephropathy (IgAN) patients and reduced susceptibility to Fas-mediated apoptosis. | lld:pubmed |
| pubmed-article:11207662 | pubmed:affiliation | Department of Otolaryngology, Oita Medical University, Hazama-machi, Oita, Japan. | lld:pubmed |
| pubmed-article:11207662 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11207662 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11207662 | lld:pubmed |
