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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2001-2-5
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pubmed:abstractText |
Several N-(3-phenylpropyl)-substituted spermidine and spermine derivatives were prepared and found to be potent competitive inhibitors of Trypanosoma cruzi trypanothione reductase (seven compounds with Ki values < 5 microM are described). The most effective inhibitor studied was compound 12 with a Ki value of 0.151 microM. Six of the compounds described are also effective trypanocides with IC50 values < 1 microM.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0960-894X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
22
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
251-4
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11206471-Animals,
pubmed-meshheading:11206471-Binding, Competitive,
pubmed-meshheading:11206471-Combinatorial Chemistry Techniques,
pubmed-meshheading:11206471-Enzyme Inhibitors,
pubmed-meshheading:11206471-Inhibitory Concentration 50,
pubmed-meshheading:11206471-Kinetics,
pubmed-meshheading:11206471-NADH, NADPH Oxidoreductases,
pubmed-meshheading:11206471-Polyamines,
pubmed-meshheading:11206471-Spermidine,
pubmed-meshheading:11206471-Spermine,
pubmed-meshheading:11206471-Structure-Activity Relationship,
pubmed-meshheading:11206471-Trypanocidal Agents,
pubmed-meshheading:11206471-Trypanosoma brucei brucei,
pubmed-meshheading:11206471-Trypanosoma cruzi
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pubmed:year |
2001
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pubmed:articleTitle |
Polyamines with N-(3-phenylpropyl) substituents are effective competitive inhibitors of trypanothione reductase and trypanocidal agents.
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pubmed:affiliation |
Department of Chemistry, Indiana State University, Terre Haute 47809, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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