Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5507
pubmed:dateCreated
2001-2-22
pubmed:abstractText
How genes with newly characterized functions originate remains a fundamental question. PMCHL1 and PMCHL2, two chimeric genes derived from the melanin-concentrating hormone (MCH) gene, offer an opportunity to examine such an issue in the human lineage. Detailed structural, expression, and phylogenetic analysis showed that the PMCHL1 gene was created near 25 million years ago (Ma) by a complex mechanism of exon shuffling through retrotransposition of an antisense MCH messenger RNA coupled to de novo creation of splice sites. PMCHL2 arose 5 to 10 Ma by an event of duplication involving a large chromosomal region encompassing the PMCHL1 locus. The RNA expression patterns of those chimeric genes suggest that they have been submitted to strong regulatory constraints during primate evolution.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0036-8075
pubmed:author
pubmed:issnType
Print
pubmed:day
16
pubmed:volume
291
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1293-7
pubmed:dateRevised
2007-3-19
pubmed:meshHeading
pubmed-meshheading:11181993-Animals, pubmed-meshheading:11181993-Chromosomes, Human, Pair 5, pubmed-meshheading:11181993-Evolution, Molecular, pubmed-meshheading:11181993-Exons, pubmed-meshheading:11181993-Gene Duplication, pubmed-meshheading:11181993-Gene Expression, pubmed-meshheading:11181993-Gene Expression Regulation, pubmed-meshheading:11181993-Haplorhini, pubmed-meshheading:11181993-Hominidae, pubmed-meshheading:11181993-Humans, pubmed-meshheading:11181993-Hypothalamic Hormones, pubmed-meshheading:11181993-Introns, pubmed-meshheading:11181993-Melanins, pubmed-meshheading:11181993-Models, Genetic, pubmed-meshheading:11181993-Mutation, pubmed-meshheading:11181993-Open Reading Frames, pubmed-meshheading:11181993-Phylogeny, pubmed-meshheading:11181993-Pituitary Hormones, pubmed-meshheading:11181993-Protein Precursors, pubmed-meshheading:11181993-RNA, Antisense, pubmed-meshheading:11181993-RNA Splicing, pubmed-meshheading:11181993-Retroelements
pubmed:year
2001
pubmed:articleTitle
Birth of two chimeric genes in the Hominidae lineage.
pubmed:affiliation
Institut de Pharmacologie Moléculaire et Cellulaire, UMR CNRS 6097, 660 route des Lucioles Sophia Antipolis 06560 Valbonne, France.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't