Source:http://linkedlifedata.com/resource/pubmed/id/11179693
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1-2
|
| pubmed:dateCreated |
2001-2-22
|
| pubmed:databankReference | |
| pubmed:abstractText |
Working within the EUROIMAGE full-length cDNA sequencing project we have isolated BTBD1, a novel human gene with a BTB/POZ domain. This motif is found in developmentally regulated zinc finger proteins and in the kelch family of actin-associated proteins, and is thought to mediate protein-protein interactions. The BTBD1 gene encodes a transcript of 3188 nt with an ORF of 482 amino acids and a predicted protein product size of 52.7 kDa. Northern blot analysis revealed an enhanced BTBD1 expression in heart and skeletal muscle. We have identified a paralogous BTBD1 counterpart gene on chromosome 19, BTBD2. BTBD1 was mapped to chromosome 15q24. Conservation of multiple pairs of genes between 15q24 and 19p13.3-p12 suggests their possible common chromosomal origin. We show the existence of the murine BTBD1 and BTBD2 orthologous genes, as well as the partial rat and bovine homologs.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
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| pubmed:issn |
0378-1119
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
10
|
| pubmed:volume |
262
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
275-81
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:11179693-Amino Acid Sequence,
pubmed-meshheading:11179693-Animals,
pubmed-meshheading:11179693-Chromosomes, Human, Pair 15,
pubmed-meshheading:11179693-Chromosomes, Human, Pair 19,
pubmed-meshheading:11179693-Cloning, Molecular,
pubmed-meshheading:11179693-DNA-Binding Proteins,
pubmed-meshheading:11179693-Expressed Sequence Tags,
pubmed-meshheading:11179693-Gene Expression Regulation,
pubmed-meshheading:11179693-Heart,
pubmed-meshheading:11179693-Humans,
pubmed-meshheading:11179693-Mice,
pubmed-meshheading:11179693-Molecular Sequence Data,
pubmed-meshheading:11179693-Muscle, Skeletal,
pubmed-meshheading:11179693-Protein Structure, Tertiary,
pubmed-meshheading:11179693-Sequence Homology, Amino Acid,
pubmed-meshheading:11179693-Transcription Factors,
pubmed-meshheading:11179693-Zinc Fingers
|
| pubmed:year |
2001
|
| pubmed:articleTitle |
Identification and characterization of BTBD1, a novel BTB domain containing gene on human chromosome 15q24.
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| pubmed:affiliation |
Medical and Molecular Genetics Center, Institut de Recerca Oncològica, Hospital Duran i Reynals, Av. Gran Via s/n km 2,7L'Hospitalet de Llobregat, 08907, Barcelona, Spain.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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