Source:http://linkedlifedata.com/resource/pubmed/id/11173925
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2001-2-22
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| pubmed:abstractText |
The neuroprotective effects of the NMDA antagonists MK-801 and ketamine were analyzed in a mutant strain of Han-Wistar rats which develop neurodegeneration in the hippocampus and cerebellum. Previous experiments have shown that the progressive neuronal degeneration observed in this mutant may be the result of a dysfunctional glutamatergic system. For MK-801 studies, mutants were injected in a chronic paradigm with (+)MK-801 or its weaker acting isomer (-)MK-801 at a dose of 1 mg/kg. Ketamine studies consisted of both acute (50 mg/kg once) and chronic (10 mg/kg multiple times) injection paradigms. MK-801-treated mutants exhibited longer life spans (8-23%) compared to saline-injected mutants. Ketamine-injected mutants in both paradigms also lived slightly longer (6-9%) than the saline mutants. Motor skill deterioration was monitored in an open-field test, and after 50 days of age the MK-801 and ketamine mutants displayed over 20% greater motor skill activity than the saline mutants. In the cerebellum, mutants treated with ketamine and both forms of MK-801 had 10-20% more Purkinje cells surviving at 55 days than the saline mutants. Further, the density of CA3c pyramidal hippocampal neurons in ketamine and MK-801-treated mutants as compared to saline mutants appeared to be greater upon qualitative analysis. This study shows that these mutants derive some protective effects from the NMDA antagonists MK-801 and ketamine, confirming glutamate-induced excitotoxicity as a possible cause of neuronal degeneration in this mutant strain of rat.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Dizocilpine Maleate,
http://linkedlifedata.com/resource/pubmed/chemical/Excitatory Amino Acid Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Glutamic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Ketamine,
http://linkedlifedata.com/resource/pubmed/chemical/Neuroprotective Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Neurotoxins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, N-Methyl-D-Aspartate
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| pubmed:status |
MEDLINE
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| pubmed:issn |
0378-5866
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| pubmed:author | |
| pubmed:copyrightInfo |
Copyright 2001 S. Karger AG, Basel
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| pubmed:issnType |
Print
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| pubmed:volume |
23
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
31-40
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:11173925-Animals,
pubmed-meshheading:11173925-Cell Survival,
pubmed-meshheading:11173925-Dizocilpine Maleate,
pubmed-meshheading:11173925-Excitatory Amino Acid Antagonists,
pubmed-meshheading:11173925-Glutamic Acid,
pubmed-meshheading:11173925-Hippocampus,
pubmed-meshheading:11173925-Ketamine,
pubmed-meshheading:11173925-Longevity,
pubmed-meshheading:11173925-Muscle Spasticity,
pubmed-meshheading:11173925-Neurodegenerative Diseases,
pubmed-meshheading:11173925-Neuroprotective Agents,
pubmed-meshheading:11173925-Neurotoxins,
pubmed-meshheading:11173925-Purkinje Cells,
pubmed-meshheading:11173925-Pyramidal Cells,
pubmed-meshheading:11173925-Rats,
pubmed-meshheading:11173925-Rats, Mutant Strains,
pubmed-meshheading:11173925-Rats, Wistar,
pubmed-meshheading:11173925-Receptors, N-Methyl-D-Aspartate
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| pubmed:year |
2001
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| pubmed:articleTitle |
Effect of the noncompetitive NMDA antagonists MK-801 and ketamine on the spastic Han-Wistar mutant: a rat model of excitotoxicity.
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| pubmed:affiliation |
Department of Biology, California State University at Northridge, Calif. 91330, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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