Linked Life Data

11172300

Source:http://linkedlifedata.com/resource/pubmed/id/11172300

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2001-2-22
pubmed:abstractText
Abnormalities of the cell cycle are present in all neoplasms. Cyclin E, which regulates the G1/S phase transition of the cell cycle, plays an important role in many different cancers. To further investigate the role of cyclin E in invasive breast ductal carcinomas in South African women, representative sections from 157 mastectomy and axillary clearance specimens were stained with the cyclin E antibody. The results were compared with known clinicopathologic prognostic factors, namely lymph node metastases, size, estrogen receptor status, and histologic grade. Positive (nuclear) cyclin E immunostaining strongly correlates with negative estrogen receptor status and high grade. These correlations may account for the observation that although cyclin E staining is associated with poor prognosis in univariate analysis, no prognostic significance remains after multivariate analysis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0046-8177
pubmed:author
pubmed:issnType
Print
pubmed:volume
32
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
89-94
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2001
pubmed:articleTitle
Cyclin E immunoexpression in breast ductal carcinoma: pathologic correlations and prognostic implications.
pubmed:affiliation
Department of Pathology, Nelson R. Mandela School of Medicine, University of Natal, Durban, South Africa.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't