Linked Life Data

111709

Source:http://linkedlifedata.com/resource/pubmed/id/111709

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
14
pubmed:dateCreated
1979-10-26
pubmed:abstractText
Nerve growth factor is a highly specific protease that can convert plasminogen to plasmin and that can hydrolyze certain synthetic N-substituted arginine esters (e.g., Nalpha=p-toluenesulfonyl-L-arginine methyl ester (TAME); N.S. Orenstein et al. (1978) Proc. Natl. Acad. Sci. U.S.A. 75, 5497). Hydrolysis of TAME is characterized by a lag phase of lower velocity which precedes development of the steady-state maximal velcity. Kinetic analyses indicate that this behavior stems from autocatalytic activation of a nerve growth factor (NGF)-zymogen by NGF. As isolated from the mouse submandibular gland at high concentration, NGF is largely enzymically inactive. Upon high dilution, the protein undergoes autocatalytic activation with concomitant generation of full enzymic activity. The biologic significance of this unusual property of NGF is not clear, but it may serve to prevent expression of enzymic activity until the protein reaches its target cell(s) or until it recognizes its physiological substrate.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0006-2960
pubmed:author
pubmed:issnType
Print
pubmed:day
10
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3050-5
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1979
pubmed:articleTitle
Proteolytic activity of nerve growth factor: a case of autocatalytic activation.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.