Linked Life Data

11170006

Source:http://linkedlifedata.com/resource/pubmed/id/11170006

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2001-2-22
pubmed:abstractText
To verify the anatomical and functional connection of the lateral septum (LS) and periaqueductal gray (PAG) in inhibiting female sexual behavior, lordosis, in male rats, retrograde (Fluoro-Gold, FG) or anterograde (Phaseolus vulgaris-leucoagglutinin, PHA-L) tracer was injected into the PAG or LS on the right side, respectively, and FG-labeled cells or PHA-L-labeled axons in the forebrain and mesencephalon were determined in estrogen-treated castrated male rats. A ventral cut (VC) of the septum and a behavioral test were also conducted in some FG-injected rats. Furthermore, lordosis behavior was observed after chemical destruction of the septum by ibotenate. As a result, the lordosis quotient (LQ) in VC males was higher than that in control males without VC. FG-labeled neuronal cell bodies were found in the ipsilateral intermediate part of the LS in the control males but not in this area of the VC males. When neuronal cells in the intermediate part of the bilateral LS were completely destroyed by ibotenate, the LQ was higher than that in sham-lesioned male rats. These results suggest that a direct neural connection of the intermediate LS to the PAG has an inhibitory role in regulating lordosis in male rats. In addition, neuronal cell bodies in the intermediate LS exert an inhibitory influence. In the PHA-L experiment, labeled axons were seen in the ventral part of the LS, the medial forebrain bundle at the chiasmatic level, the lateral hypothalamus, the median region of the mesencephalon, and the rostral PAG in the side ipsilateral to the tracer injection site of the LS. Thus, these areas are thought to be involved in the pathway for lordosis-inhibition from the intermediate part of the LS to the PAG in male rats.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0021-9967
pubmed:author
pubmed:copyrightInfo
Copyright 2001 Wiley-Liss, Inc.
pubmed:issnType
Print
pubmed:day
12
pubmed:volume
431
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
293-310
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:11170006-Animals, pubmed-meshheading:11170006-Excitatory Amino Acid Agonists, pubmed-meshheading:11170006-Female, pubmed-meshheading:11170006-Fluorescent Dyes, pubmed-meshheading:11170006-Ibotenic Acid, pubmed-meshheading:11170006-Immunohistochemistry, pubmed-meshheading:11170006-Male, pubmed-meshheading:11170006-Neural Pathways, pubmed-meshheading:11170006-Neurons, pubmed-meshheading:11170006-Periaqueductal Gray, pubmed-meshheading:11170006-Phytohemagglutinins, pubmed-meshheading:11170006-Posture, pubmed-meshheading:11170006-Rats, pubmed-meshheading:11170006-Rats, Wistar, pubmed-meshheading:11170006-Septal Nuclei, pubmed-meshheading:11170006-Sex Characteristics, pubmed-meshheading:11170006-Sexual Behavior, Animal, pubmed-meshheading:11170006-Stilbamidines, pubmed-meshheading:11170006-Ventromedial Hypothalamic Nucleus
pubmed:year
2001
pubmed:articleTitle
Neurohistological and behavioral evidence for lordosis-inhibiting tract from lateral septum to periaqueductal gray in male rats.
pubmed:affiliation
Advanced Research Center for Human Sciences, Waseda University, Saitama 359-1192, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't