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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2001-2-22
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pubmed:abstractText |
The activation of protein kinase C (PKC) and transforming growth factor-beta (TGF-beta) in glomerular mesangial cells has been linked to mesangial matrix expansion in diabetic nephropathy. The role of these mediators in affecting the changes associated with diabetes in the biology of glomerular endothelial cells (GEnCs), which synthesize components of the glomerular basement membrane, is not known. We postulated that the PKC and TGF-beta systems promote the increased endothelial cell synthesis of glomerular basement membrane that is evoked by Amadori-modified glycated albumin, which is present in elevated concentrations in diabetes.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0085-2538
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
59
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
673-81
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:11168949-Animals,
pubmed-meshheading:11168949-Cell Division,
pubmed-meshheading:11168949-Collagen,
pubmed-meshheading:11168949-Endothelium, Vascular,
pubmed-meshheading:11168949-Kidney Glomerulus,
pubmed-meshheading:11168949-Mice,
pubmed-meshheading:11168949-Protein Kinase C,
pubmed-meshheading:11168949-Serum Albumin,
pubmed-meshheading:11168949-Transforming Growth Factor beta,
pubmed-meshheading:11168949-Transforming Growth Factor beta1
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pubmed:year |
2001
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pubmed:articleTitle |
Glycated albumin stimulates TGF-beta 1 production and protein kinase C activity in glomerular endothelial cells.
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pubmed:affiliation |
Renal-Electrolyte and Hypertension Division, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6144, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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