| pubmed-article:11166928 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11166928 | lifeskim:mentions | umls-concept:C0034715 | lld:lifeskim |
| pubmed-article:11166928 | lifeskim:mentions | umls-concept:C0028351 | lld:lifeskim |
| pubmed-article:11166928 | lifeskim:mentions | umls-concept:C0006549 | lld:lifeskim |
| pubmed-article:11166928 | lifeskim:mentions | umls-concept:C0028246 | lld:lifeskim |
| pubmed-article:11166928 | lifeskim:mentions | umls-concept:C0221912 | lld:lifeskim |
| pubmed-article:11166928 | lifeskim:mentions | umls-concept:C0312418 | lld:lifeskim |
| pubmed-article:11166928 | lifeskim:mentions | umls-concept:C0021376 | lld:lifeskim |
| pubmed-article:11166928 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:11166928 | lifeskim:mentions | umls-concept:C0036667 | lld:lifeskim |
| pubmed-article:11166928 | lifeskim:mentions | umls-concept:C1705241 | lld:lifeskim |
| pubmed-article:11166928 | lifeskim:mentions | umls-concept:C1705242 | lld:lifeskim |
| pubmed-article:11166928 | pubmed:issue | 1-2 | lld:pubmed |
| pubmed-article:11166928 | pubmed:dateCreated | 2001-2-22 | lld:pubmed |
| pubmed-article:11166928 | pubmed:abstractText | We investigated whether there are any differences between the Lewis and Sprague-Dawley (SD) rats in chronic inflammation-induced norepinephrine (NE) sensitivity of nociceptors. Activities of C-fiber nociceptors innervating rat hairy hindpaw skin were recorded in an in vitro skin-nerve preparation. Sixty-five percent of C-fibers from inflamed Lewis rats were excited by NE (10 microM), against only 38% of C-fibers from inflamed SD rats. The average of the total impulses evoked in response to NE was also significantly higher in Lewis rats. The alpha2-adrenoceptor antagonist CH 38083 (10 microM) and yohimbine (10 microM) consistently blocked the NE-excitation of both strains. These results show that after chronic inflammation, C-fiber nociceptors of Lewis strain rats have a stronger sensitivity to NE, and that alpha2-adrenoceptors are predominately involved in the NE-sensitivity of inflamed rats in both strains. | lld:pubmed |
| pubmed-article:11166928 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11166928 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11166928 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11166928 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11166928 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11166928 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11166928 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11166928 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11166928 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:11166928 | pubmed:issn | 0304-3940 | lld:pubmed |
| pubmed-article:11166928 | pubmed:author | pubmed-author:YajimaHH | lld:pubmed |
| pubmed-article:11166928 | pubmed:author | pubmed-author:SatoJJ | lld:pubmed |
| pubmed-article:11166928 | pubmed:author | pubmed-author:MizumuraKK | lld:pubmed |
| pubmed-article:11166928 | pubmed:author | pubmed-author:BanikR KRK | lld:pubmed |
| pubmed-article:11166928 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11166928 | pubmed:day | 16 | lld:pubmed |
| pubmed-article:11166928 | pubmed:volume | 299 | lld:pubmed |
| pubmed-article:11166928 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11166928 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11166928 | pubmed:pagination | 21-4 | lld:pubmed |
| pubmed-article:11166928 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:11166928 | pubmed:meshHeading | pubmed-meshheading:11166928... | lld:pubmed |
| pubmed-article:11166928 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11166928 | pubmed:articleTitle | Differences between the Lewis and Sprague-Dawley rats in chronic inflammation induced norepinephrine sensitivity of cutaneous C-fiber nociceptors. | lld:pubmed |
| pubmed-article:11166928 | pubmed:affiliation | Department of Neural Regulation, Research Institute of Environmental Medicine, Nagoya University, Nagoya 464-8601, Japan. | lld:pubmed |
| pubmed-article:11166928 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11166928 | pubmed:publicationType | Comparative Study | lld:pubmed |
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