Source:http://linkedlifedata.com/resource/pubmed/id/11166928
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1-2
|
| pubmed:dateCreated |
2001-2-22
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| pubmed:abstractText |
We investigated whether there are any differences between the Lewis and Sprague-Dawley (SD) rats in chronic inflammation-induced norepinephrine (NE) sensitivity of nociceptors. Activities of C-fiber nociceptors innervating rat hairy hindpaw skin were recorded in an in vitro skin-nerve preparation. Sixty-five percent of C-fibers from inflamed Lewis rats were excited by NE (10 microM), against only 38% of C-fibers from inflamed SD rats. The average of the total impulses evoked in response to NE was also significantly higher in Lewis rats. The alpha2-adrenoceptor antagonist CH 38083 (10 microM) and yohimbine (10 microM) consistently blocked the NE-excitation of both strains. These results show that after chronic inflammation, C-fiber nociceptors of Lewis strain rats have a stronger sensitivity to NE, and that alpha2-adrenoceptors are predominately involved in the NE-sensitivity of inflamed rats in both strains.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0304-3940
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
16
|
| pubmed:volume |
299
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
21-4
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:11166928-Action Potentials,
pubmed-meshheading:11166928-Animals,
pubmed-meshheading:11166928-Chronic Disease,
pubmed-meshheading:11166928-Freund's Adjuvant,
pubmed-meshheading:11166928-Ganglia, Spinal,
pubmed-meshheading:11166928-Inflammation,
pubmed-meshheading:11166928-Nerve Fibers,
pubmed-meshheading:11166928-Neurons, Afferent,
pubmed-meshheading:11166928-Nociceptors,
pubmed-meshheading:11166928-Norepinephrine,
pubmed-meshheading:11166928-Pain,
pubmed-meshheading:11166928-Rats,
pubmed-meshheading:11166928-Rats, Inbred Lew,
pubmed-meshheading:11166928-Rats, Sprague-Dawley,
pubmed-meshheading:11166928-Receptors, Adrenergic, alpha-2,
pubmed-meshheading:11166928-Skin,
pubmed-meshheading:11166928-Sympathetic Fibers, Postganglionic,
pubmed-meshheading:11166928-Sympathomimetics
|
| pubmed:year |
2001
|
| pubmed:articleTitle |
Differences between the Lewis and Sprague-Dawley rats in chronic inflammation induced norepinephrine sensitivity of cutaneous C-fiber nociceptors.
|
| pubmed:affiliation |
Department of Neural Regulation, Research Institute of Environmental Medicine, Nagoya University, Nagoya 464-8601, Japan.
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| pubmed:publicationType |
Journal Article,
Comparative Study
|