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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2001-2-22
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pubmed:databankReference |
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF170029,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF170030,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF170031,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF170032,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF170033,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF170034,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF170035,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF170036,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF170037,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF170038,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF170039,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF170040,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF170041,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF170042,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF170043,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF170044,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF170045,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF170046,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF170047,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF170048,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF170049,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF170050,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF170051,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF170052,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF170053,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF170054,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF170055,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF170056,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF170057,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF170058,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF170059,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF170060,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF170061
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pubmed:abstractText |
To determine the prevalence of human immunodeficiency virus type 2 (HIV-2) subtypes circulating in France and to identify possible relationships between these subtypes and pathogenesis, we studied 33 HIV-2-infected patients living in France. HIV-2 DNA was directly amplified from peripheral blood mononuclear cells by nested PCR with specific HIV-2 env primers, and the env gene was sequenced. The serological consequences of antigenic variability were studied by using a panel of peptides and by Western blotting. Phylogenetic analysis classified the 33 HIV-2 strains as subtype A (n = 23) or B (n = 10). There were no significant clinical or epidemiological differences between patients infected with either of these two subtypes. There was some evidence for geographical clustering. Subtype A strains from patients originating from the Cape Verde Islands and Guinea Bissau clustered together. The majority of patients infected with subtype B strains originated from the Ivory Coast or Mali. Strains from patients originating in Mali also clustered in subtype A but distinctly from the Cape Verde or Guinea Bissau strains. The subtype B strains showed greater diversity and included some highly divergent strains relative to those previously characterized. The V3 loop of HIV-2 subtypes A and B was found to be quite conserved in comparison with HIV-1. A strong HIV-2 subtype B serological cross-reactivity was found on HIV-1 env antigen by Western blot mostly in the gp41 transmembrane glycoprotein. This could partly explain the double HIV-1 and HIV-2 reactive profiles found in countries where HIV-2 subtype B is prevalent.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Amino Acids,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Gene Products, env,
http://linkedlifedata.com/resource/pubmed/chemical/HIV Antibodies,
http://linkedlifedata.com/resource/pubmed/chemical/HIV Envelope Protein gp120,
http://linkedlifedata.com/resource/pubmed/chemical/HIV Envelope Protein gp160,
http://linkedlifedata.com/resource/pubmed/chemical/HIV Envelope Protein gp41,
http://linkedlifedata.com/resource/pubmed/chemical/HIV envelope protein gp120 (305-321),
http://linkedlifedata.com/resource/pubmed/chemical/Immunodominant Epitopes,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0042-6822
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2001 Academic Press.
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
280
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
19-30
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:11162815-Humans,
pubmed-meshheading:11162815-Infant,
pubmed-meshheading:11162815-Amino Acids,
pubmed-meshheading:11162815-Peptides,
pubmed-meshheading:11162815-France,
pubmed-meshheading:11162815-Peptide Fragments,
pubmed-meshheading:11162815-Female,
pubmed-meshheading:11162815-Male,
pubmed-meshheading:11162815-Genetic Variation,
pubmed-meshheading:11162815-Adult,
pubmed-meshheading:11162815-Middle Aged,
pubmed-meshheading:11162815-Base Sequence,
pubmed-meshheading:11162815-DNA, Viral,
pubmed-meshheading:11162815-Amino Acid Sequence,
pubmed-meshheading:11162815-Binding Sites,
pubmed-meshheading:11162815-Prevalence,
pubmed-meshheading:11162815-Molecular Sequence Data,
pubmed-meshheading:11162815-Phylogeny,
pubmed-meshheading:11162815-Sequence Homology, Amino Acid,
pubmed-meshheading:11162815-Epitope Mapping,
pubmed-meshheading:11162815-Blotting, Western,
pubmed-meshheading:11162815-HIV Antibodies,
pubmed-meshheading:11162815-HIV Infections,
pubmed-meshheading:11162815-HIV Envelope Protein gp41,
pubmed-meshheading:11162815-HIV Envelope Protein gp120
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