| pubmed-article:11161706 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11161706 | lifeskim:mentions | umls-concept:C1154382 | lld:lifeskim |
| pubmed-article:11161706 | lifeskim:mentions | umls-concept:C0081938 | lld:lifeskim |
| pubmed-article:11161706 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:11161706 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:11161706 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:11161706 | pubmed:dateCreated | 2001-2-22 | lld:pubmed |
| pubmed-article:11161706 | pubmed:abstractText | Integrins are highly regulated receptors that can function in both cell-substrate and cell-cell adhesion. We have found that the activating anti-beta1 mAb, 12G10, can specifically and rapidly induce both cell-substrate and cell-cell adhesion of HT-1080 human fibrosarcoma and other cell types. Binding of mAb 12G10 induced clustering of cell-surface integrins, and the preferential localization of beta1 integrins expressing the 12G10 epitope at cell-cell adhesion sites. Fab fragments of mAb 12G10 induced HT-1080 cell-cell adhesion as effectively as did intact antibodies, suggesting that integrin clustering was not due to direct antibody crosslinking. Latrunculin B, an inhibitor of F-actin polymerization, inhibited cell-cell adhesion but not the clustering of integrins. Results from a novel, two-color cell-cell adhesion assay suggested that nonactivated cells can bind to activated cells and that integrin activation-induced HT-1080 cell-cell adhesion minimally requires the interaction of activated alpha2beta1 with nonactivated alpha3beta1. These findings suggest that HT-1080 cell-cell adhesion induced by integrin activation require a signaling process involving integrin clustering and the subsequent organization of the cytoskeleton. Integrin activation could therefore play a key role in cell-cell adhesion. | lld:pubmed |
| pubmed-article:11161706 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11161706 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11161706 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11161706 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11161706 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11161706 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11161706 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11161706 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11161706 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11161706 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11161706 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11161706 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11161706 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:11161706 | pubmed:issn | 0014-4827 | lld:pubmed |
| pubmed-article:11161706 | pubmed:author | pubmed-author:AkiyamaS KSK | lld:pubmed |
| pubmed-article:11161706 | pubmed:author | pubmed-author:WhittardJ DJD | lld:pubmed |
| pubmed-article:11161706 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11161706 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:11161706 | pubmed:volume | 263 | lld:pubmed |
| pubmed-article:11161706 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11161706 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11161706 | pubmed:pagination | 65-76 | lld:pubmed |
| pubmed-article:11161706 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:11161706 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11161706 | pubmed:articleTitle | Activation of beta1 integrins induces cell-cell adhesion. | lld:pubmed |
| pubmed-article:11161706 | pubmed:affiliation | Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA. | lld:pubmed |
| pubmed-article:11161706 | pubmed:publicationType | Journal Article | lld:pubmed |
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