Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2001-2-22
pubmed:abstractText
Apolipoprotein E plays an important role in recovery from acute brain injury and risk of developing Alzheimer's disease. We demonstrate that biologically relevant concentrations of apoE suppress microglial activation and release of TNFalpha and NO in a dose-dependent fashion. Peptides derived from the apoE receptor-binding region mimic the effects of the intact protein, whereas deletion of apoE residues 146-149 abolishes peptide bioactivity. These results are consistent with the hypothesis that apoE modulates microglial function by binding specific cell surface receptors and that the immunomodulatory effects of apoE in the central nervous system may account for its role in acute and chronic neurological disease.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0014-4886
pubmed:author
pubmed:issnType
Print
pubmed:volume
167
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
74-85
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:11161595-Animals, pubmed-meshheading:11161595-Apolipoproteins E, pubmed-meshheading:11161595-Binding Sites, pubmed-meshheading:11161595-Cell Survival, pubmed-meshheading:11161595-Cells, Cultured, pubmed-meshheading:11161595-Circular Dichroism, pubmed-meshheading:11161595-Dose-Response Relationship, Drug, pubmed-meshheading:11161595-Down-Regulation, pubmed-meshheading:11161595-Humans, pubmed-meshheading:11161595-Low Density Lipoprotein Receptor-Related Protein-1, pubmed-meshheading:11161595-Mice, pubmed-meshheading:11161595-Mice, Inbred C57BL, pubmed-meshheading:11161595-Mice, Knockout, pubmed-meshheading:11161595-Microglia, pubmed-meshheading:11161595-Neuroglia, pubmed-meshheading:11161595-Nitric Oxide, pubmed-meshheading:11161595-Peptide Fragments, pubmed-meshheading:11161595-Protein Isoforms, pubmed-meshheading:11161595-Protein Structure, Secondary, pubmed-meshheading:11161595-Receptors, Immunologic, pubmed-meshheading:11161595-Recombinant Proteins, pubmed-meshheading:11161595-Sequence Deletion, pubmed-meshheading:11161595-Structure-Activity Relationship, pubmed-meshheading:11161595-Substrate Specificity, pubmed-meshheading:11161595-Tumor Necrosis Factor-alpha
pubmed:year
2001
pubmed:articleTitle
Downregulation of microglial activation by apolipoprotein E and apoE-mimetic peptides.
pubmed:affiliation
Department of Medicine (Neurology), Duke University Medical Center, Durham, North Carolina 27710, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't